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Neuropediatrics 2007; 38(1): 18-24
DOI: 10.1055/s-2007-981450
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

The Relative Contributions of Brain, Cerebrospinal Fluid-Filled Structures and Non-Neural Tissue Volumes to Occipital-Frontal Head Circumference in Subjects with Autism

D. F. Tate 1 , 2 , E. D. Bigler 3 , 4 , W. McMahon 4 , J. Lainhart 4
  • 1Center for Neurological Imaging, Brigham and Women's Hospital, Boston, MA, USA
  • 2Department of Psychiatry and Behavioral Medicine, Brown Medical School, Providence, RI, USA
  • 3Departments of Psychology and Neuroscience, Brigham Young University, Provo, UT, USA
  • 4Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
Further Information

Publication History

received 19.12.2006

accepted 26.3.2007

Publication Date:
02 July 2007 (online)

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Abstract

An increased prevalence of macrocephaly defined by occipital-frontal circumference (OFC) is a consistent finding in autism. Several possible mechanisms have been proposed, the most compelling being early brain overgrowth. However, the proportion of non-neural tissues (NNT) that contribute to OFC has not been reported. Using quantitative magnetic resonance imaging (MRI) methods we analyzed the relationships between OFC and total brain (TBV), ventricular, surface cerebrospinal fluid (CSF)/meningeal, and NNT volumes in subjects with autism. Sixty male subjects (34 autistic; 26 controls) seven years of age and older were used in this study. Compared to other measures, NNT volume was most significantly related to OFC (r values > 0.8, p≤0.001), though NNT volume did not differ between the groups. Ventricular volume was also uniformly related to OFC (r≈0.3, p> 0.06). In contrast, the OFC-TBV relationship was less robust in those with autism (r=0.25, p≤0.09) and only significant in the controls (r=0.58, p≤0.001). Conversely, subjects with autism had a more robust and significantly different relationship between subarachnoid CSF/meningeal volume than controls (r=0.53 and 0.24; p≤0.001 and 0.12, respectively). Possible explanations for these findings are discussed in the context of potential OFC differences that may occur in accelerated early brain growth associated with autism.

Key words

Autism - MRI - brain overgrowth - head circumference

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Correspondence

D. F. TatePhD 

Center for Neurological Imaging

221 Longwood Ave

Boston, MA

02115

USA

Phone: 617/732 86 00

Email: dtate1@partners.org

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