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Horm Metab Res 1997; 29(9): 417-421
DOI: 10.1055/s-2007-979068
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© Georg Thieme Verlag Stuttgart · New York

GLP-1 (7 - 36) Amide: Effects on Glucose Transport and Metabolism in Rat Adipose Tissue

A. Perea, C. Viñambres, F. Clemente, M. L. Villanueva-Peñacarrillo, I. Valverde
  • Department of Metabolism, Nutrition and Hormones, Fundación Jiménez Díaz, Madrid, Spain
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Publication History

1996

1997

Publication Date:
23 April 2007 (online)

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In rat adipocytes, GLP-1 (7-36) amide induced an increment in 2-deoxy-glucose uptake, which was additive to that of insulin. Furthermore, in rat fat, GLP-1 (7-36) amide provoked a rise in glycogen synthesis, glucose oxidation and utilization and lipogenesis, the increments being lower than those obtained with insulin. These data support the idea that GLP-1 exerts insulin-like effects on glucose metabolism in rat adipose tissue, as it does in rat hepatocytes and skeletal muscle, although with a lower potency than that of insulin.

Key words

GLP-1 - Adipose Tissue - Glucose Metabolism - Glucose Transport

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