A Case of Myasthenia Gravis in Childhood Associated with Chronic Inflammatory Demyelinating Polyradiculoneuropathy

K. Kimura; A. Nezu; S. Kimura; N. Otsuki; T. Kobayashi; Y. Nomura; M. Segawa

doi:10.1055/s-2007-973544

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Neuropediatrics 1998; 29(2): 108-112
DOI: 10.1055/s-2007-973544

Short communications

A Case of Myasthenia Gravis in Childhood Associated with Chronic Inflammatory Demyelinating Polyradiculoneuropathy

K. Kimura¹ ^, ² , A. Nezu¹ , S. Kimura¹ , N. Otsuki¹ , T. Kobayashi¹ , Y. Nomura² , M. Segawa²

¹Yokohama City University School of Medicine,
²Segawa Neurological Clinic for Children, Japan

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Publication History

Publication Date:
12 March 2007 (online)

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Abstract

We report a 14-year-old girl who developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) during the course of myasthenia gravis. Myasthenia gravis, which was clinically of ocular type, but with waning phenomenon of the extremities, occurred at 2 years and 4 months of age. Muscle weakness of the lower extremities gradually developed over the next 6 years.

The electrophysiological and pathological findings fulfilled the criteria of "possible CIDP" with severe axonal involvement. The signs of myasthenia gravis and CIDP fluctuated synchronously. A common immunological abnormality was suggested to underlie this rare association of myasthenia gravis and CIDP in childhood.

Key words

Myasthenia gravis - Chronic inflammatory demyelinating polyradiculoneuropathy - Cyclophospha-mide - High-dose γ-globulin

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