Alkaloids from Annonaceae; LV1. Chemistry and Pharmacology of Cymbopetalum brasiliense

A. Cavé; D. Debourges; G. Lewin; C. Moretti; Ch. Dupont

doi:10.1055/s-2007-969787

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Planta Med 1984; 50(6): 517-519
DOI: 10.1055/s-2007-969787

Research Articles

Alkaloids from Annonaceae; LV¹. Chemistry and Pharmacology of Cymbopetalum brasiliense

A. Cavé² , D. Debourges² , G. Lewin² , C. Moretti³ , Ch. Dupont²

²Laboratoire de Pharmacognosie, ERA 317 CNRS et Laboratoire de Pharmacologic, ERA 627 CNRS Faculté de Pharmacie, F-92290 Châtenay-Malabry, France
³Centre ORSTOM, BP 165, Cayenne, Guyane

1 Part LIV: Hocquemiller, R.; Rasamizafy, S.; Moretti, C; Cavé, A. (1984), Plantes Medicinales et Phytoth., in press

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Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

An aqueous extract of bark of Cymbopetalum brasiliense exerts a positive inotropic action on the isolated and perfused rat heart. This activity is due to quaternary alkaloids. Four quaternary alkaloids have been isolated and tested in vivo and in vitro: magnoflorine, N-methylisocorypalmine (a new alkaloid), tembetarine, and colletine. These last three alkaloids seem to be responsible for the inotropic activity.