Planta Med 1984; 50(6): 492-496
DOI: 10.1055/s-2007-969781
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Studies on Coumarins of a Chinese Drug “Qian-Hu”; VI1, Coumarins of Angelica edulis

C. Kawasaki2 , T. Okuyama2 , S. Shibata2 , Y. Iitaka3
  • 2Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Nozawa 1-35-23, Setagaya-ku, Tokyo, Japan
  • 3Faculty of Pharmaceutical Sciences, University of Tokyo
1 Part V of this series: Asahara, R., Sakakibara, I., Okuyama, T., Shibata, S. (1984) Planta Med. 50, 488-492
Further Information

Publication History

1984

1984

Publication Date:
26 February 2007 (online)

Abstract

Coumarins, edulisin I (Ae-I) (1) and edulisin II (Ae-VI) (6), were isolated from ether extracts of the roots and rhizomes of Angelica edulis Miyabe (Umbelliferae), together with five known coumarins. The structures of edulisin I (1) and edulisin II (6) were established to be 2′ (S), 3′ (R)-3′-senesioyloxy-O-trans-p-coumaroyl-2′, 3′-dihydrooroselol and 2′ (S), 3′ (R)-senecioyloxy-O- senecioyl-2′, 3′-dihydro-oroselol by chemical studies and spectral analysis. Ae-III (3) was identified with isopeucenidin and the configuration at C-2′ and C-3′ of Ae-III (3) was assigned as R and R, respectively by chemical studies and an X-ray crystallographic analysis. Accordingly, the optical rotation of isopeucenidin reported by Steck and Wetter has been corrected.