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Planta Med 1984; 50(6): 473-477
DOI: 10.1055/s-2007-969776
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Studies on the Activities of Tannins and Related Compounds; V1. Inhibitory Effects on Lipid Peroxidation in Mitochondria and Microsomes of Liver2

Yoshiyuki Kimura3 , Hiromichi Okuda3 , Takuo Okuda4 , Tsutomu Hatano4 , Isao Agata5 , Shigeru Arichi6
  • 32nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime, 791-02, Japan
  • 4Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan
  • 5Faculty of Pharmaceutical Sciences, Higashi Nippon Gakuen University, Hokkaido, Japan
  • 6The Research Institute of Oriental Medicine, Kinki University, Osaka, Japan
1 Part IV: Kimura, Y., Okuda, H., Mori, K., Okuda, T., Arichi, S. (1984) Chem. Pharm. Bull. (Tokyo). 32, 18662 Okuda, T., Kimura, Y., Yoshida, T., Hatano, T., Okuda, H., Arichi, S. (1983) Chem. Pharm. Bull. (Tokyo), 31, 1625
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1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

The inhibitory effects of caffeoylquinic acids isloted from leaves of Artemisia species on lipid peroxidation induced by adenosine 5′-diphosphate (ADP) and ascorbic acid in rat liver mitochondria, and on that induced by ADP and nicotinamide adenine dinucleotide phosphate (NADPH) in rat liver microsomes, were determined. At the concentration of 5 × 10-5M, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid and 3,4-di-O-caffeoylquinic acid exhibited complete inhibition of lipid peroxidation induced by the two systems decribed above. The inhibitory effects of these of these dicaffeoylquinic acids were markedly higher than those of caffeic acid, chlorogenic acid and methyl chorogenate, in both systems. The inhibitory effects of these tannins in both systems were very much stronger than that of dl-α-tocopherol.