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Thorac Cardiovasc Surg 1983; 31(4): 230-233
DOI: 10.1055/s-2007-1021985
© Georg Thieme Verlag Stuttgart · New York

Phospholipase A Activation Following Extracorporeal Circulation and its Blockade by Procaine

D. Olthoff, D. Kunze, B. Rüstow
  • Clinic for Anesthesiology and Intensive Care, and Institute for Pathological and Clinical Biochemistry, Faculty of Medicine (Charité), Humboldt-University, Berlin, GDR
Further Information

Publication History

1982

Publication Date:
19 March 2008 (online)

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Summary

The phospholipase A activity of human plasma was investigated in the course of operations with the aid of extracorporeal circulation. After an initial increase following heparin application, there is a continuous rise up to the end of perfusion and a decrease to normal values 30 minutes after the end of perfusion and the application of protamine. Procaine is suitable for the Inhibition of the increased phospholipase A activity. In accordance with in vitro determinations of an effective dose of 1 mmol/ml, corresponding concentrations were attained with an infusion rate of 1.5-2 mg/kg/min. In a second series of investigations, a significantly smaller phospholipase A activation in the course of perfusion was detectable through the addition of procaine.

Key words

Extracorporeal circulation - Plasma phospholipase A - Heparin - Procaine

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