Naloxone Fails to Increase LH Levels in Clomiphene Treated Men

C. Foresta; G. Scanelli; A. Fabbri; L. Gnessi; C. Moretti; F. Fraioli

doi:10.1055/s-2007-1014721

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Horm Metab Res 1984; 16(3): 140-141
DOI: 10.1055/s-2007-1014721

Naloxone Fails to Increase LH Levels in Clomiphene Treated Men

C. Foresta¹ , G. Scanelli¹ , A. Fabbri, L. Gnessi, C. Moretti, F. Fraioli

¹Istituto di Semeiotica Medica, Università di Padova, Padova, Italy
Clinica Medica, Università di Roma, Rome, Italy

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Publikationsverlauf

1983

1983

Publikationsdatum:
14. März 2008 (online)

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Summary

The gonadotrophin response to the opiate antagonist naloxone administered per infusion has been investigated before and after 5 days of clomiphene treatment in 5 male subjects. Before clomiphene treatment, naloxone caused a significant increase in LH levels, however, after clomiphene, naloxone failed to induce the same effect. An important role for gonadal steroids on the opiatergic inhibitory tone of LH secretion in man is suggested.

Key-Words:

Naloxone - Opioids - LH - Clomiphene

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