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Horm Metab Res 1986; 18(4): 234-237
DOI: 10.1055/s-2007-1012281
ORIGINALS

© Georg Thieme Verlag, Stuttgart · New York

Influence of Thyroid Function Upon “Substance P” Induced Secretion of Saliva by Submaxillary Glands

O. R. Tumilasci, A. B. Houssay, C. del V. Paz, N. E. Sosto, V. Varela
  • 2da. Cátedra de Fisiología, Facultad de Medicina, University of Buenos Aires, Buenos Aires, Argentina
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Publication History

1984

1985

Publication Date:
14 March 2008 (online)

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Summary

The effects of changes in thyroid function on the action of “Substance P” upon the secretion of saliva by the submaxillary glands was studied in male Wistar rats, with parasympathetic decentralization on the left side. The dose-response curves to increasing doses of “Substance P” showed in hyperthyroid animals increased salivary secretion while in hypothyroid animals the dose-response curve to the drug was decreased. Every animal showed supersentivity to “Substance P” in the decentralized gland. The influence of changes in thyroid function in the denervated glands was the same as that in the unoperated side, increased salivary secretion in hyperthyroidism and decreased in hypothyroidism.

Key-Words

“Substance P” (Octapeptide) - Hyperthyroidism - Hypothyroidism - Parasympathic Decentralization - Submaxillary Glands - Secretion of Saliva

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