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Horm Metab Res 1987; 19(12): 604-605
DOI: 10.1055/s-2007-1011890
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© Georg Thieme Verlag, Stuttgart · New York

The Effect of Dopaminergic Blockade on Thyrotrophin Response to Thyrotrophin-Releasing Hormone and Somatostatin

A. Sánchez1 , E. Montoya2
  • 1Departamento de Investigación, Centro Ramón y Cajal de la Seguridad Social, Madrid, Spain
  • 2Departamento de Biología y Bioquímica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, Cádiz, Spain
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Publication History

1986

1986

Publication Date:
14 March 2008 (online)

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Summary

Using a large number of animals we have been able to demonstrate that somatostatin administration (20 μg/100 g bw) significantly reduces both basal serum thyrotrophin (TSH) levels and the response to thyrotrophin-releasing hormone (TRH) in the normal rat. Pretreatment with the dopaminergic antagonist domperidone resulted in increased TSH levels, increased response to TRH but no modification in the response to somatostatin.

Key-Words

TSH - TRH - Somatostatin - Domperidone

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