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Horm Metab Res 1988; 20(1): 40-43
DOI: 10.1055/s-2007-1010744
ORIGINALS
Basic
© Georg Thieme Verlag, Stuttgart · New York

Bone Mineral Content of the Hyperprolactinemic Rat Femur by Single Photon Absorptiometry

C. E. Fiore1 , G. Clementi2 , A. Prato2 , R. Foti1 , G. Conforto2
  • 1Department of Medical Pathology 1, University of Catania, Catania, Italy
  • 2Department of Pharmacology, University of Catania, Catania, Italy
Further Information

Publication History

1986

1987

Publication Date:
14 March 2008 (online)

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Summary

Chronic hyperprolactinemia was obtained in the rat by an implantation of two adenohypophyses under the kidney capsule. This experimental model was set to evaluate the influence that high prolactin levels may have on bone mineralization when an intervention of estrogens can reasonably be excluded.

Bone density was measured by single photon absorptiometry at the femur level. Our results indicate that the increase in PRL throughout the period of observation was associated with a significant decrease in bone mineral content, while calcium and parathyroid hormone serum levels remained unchanged.

This would suggest that PRL plays a role in bone calcium metabolism, that might be included among the effects of this hormone.

Key-Words

Hyperprolactinemia - Bone Mineral Content