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Horm Metab Res 1988; 20(1): 11-14
DOI: 10.1055/s-2007-1010737
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© Georg Thieme Verlag, Stuttgart · New York

Effect of Insulin Deficiency on Low Density Lipoprotein Metabolism in Rabbits

A. Golay, L. Zech, M.-Z. Shi, Y.-A. M. Chiou, G. M. Reaven, Y.-D. I. Chen
  • Department of Medicine, Stanford University School of Medicine, and Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, Palo Alto, U.S.A.
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Publication History

1987

1987

Publication Date:
14 March 2008 (online)

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Summary

These studies have been carried out in rabbits with alloxan-induced diabetes in order to see if insulin deficiency affects low density lipoprotein (LDL) catabolism. The results showed that plasma LDL-cholesterol was lower in diabetic rabbits, associated with a fall in the cholesterol to protein ratio of LDL particles. In addition, 125I-LDL disappeared more slowly from plasma of diabetic rabbits, leading to a significant reduction in fractional catabolic rate and a decrease in residence time of 125I-LDL. These data demonstrate that LDL composition and catabolism are greatly altered as a consequence of insulin deficiency.

Key-Words

LDL Catabolism - Cholesterol - Alloxan-Induced Diabetes - 125I-LDL Turnover - Insulin Deficiency