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J Reconstr Microsurg 1997; 13(3): 193-197
DOI: 10.1055/s-2007-1006404
DOI: 10.1055/s-2007-1006404
ORIGINAL ARTICLE
© 1997 by Thieme Medical Publishers, Inc.
The Significance of Tumor Necrosis Factor (TNF) Levels for Rejection of Joint Allograft
Further Information
Publication History
Accepted for publication 1996
Publication Date:
08 March 2008 (online)
![](https://www.thieme-connect.de/media/jrm/199703/lookinside/thumbnails/10.1055-s-2007-1006404-1.jpg)
ABSTRACT
This paper describes the efficacy of utilizing Tumor Necrosis Factor -α (TNF) as a detectable parameter of acute rejection after bone allografts. The authors used a bone-joint allograft model, transferring vas-cularized allograft knee joints across a major histocompatibility barrier, using three groups of rats divided into controls, non-immunosuppressed, and immunosuppressed with cyclosporine. The paper supplies preliminary information suggesting that TNF may be a marker for early bone-joint allograft rejection.