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DOI: 10.1055/s-2007-1002184
© Georg Thieme Verlag, Stuttgart · New York
Comparison of Plasma Pancreastatin and GAWK Concentrations, Presumed Processing Products of Chromogranin A and B, in Plasma of Patients with Pancreatic Islet Cell Tumors
Publication History
1993
1993
Publication Date:
14 March 2008 (online)
Summary
Plasma pancreastatin (PST) and GAWK, peptides processed from chromogranin A and B, were elevated in patients with various neuroendocrine tumors. In the present study, we measured plasma PST- and GAWK-like immunoreactivity (LI) concentrations in 12 patients with pancreatic islet cell tumors and evaluated them as a marker for these tumors. We also performed the gel filtration of the plasma from a gastrinoma patient and investigated the processing of PST and GAWK in plasma. Elevation of plasma PST-LI was found in 4 of 12 patients (33%) and elevation of plasma GAWK-LI was found in 6 of 12 patients (50%). A significant correlation was not found between plasma PST- and GAWK-LI concentrations of the patients. In the gel permeation chromatography of the plasma from a gastrinoma patient, PST-LI composed of a single peak but GAWK-LI composed of several components with wide range molecular weights.
Key words
Pancreastatin - GAWK - Islet Cell Tumors