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Planta Med 1988; 54(6): 492-494
DOI: 10.1055/s-2006-962526
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© Georg Thieme Verlag Stuttgart · New York

Antifertility and Hormonal Properties of Certain Carotane Sesquiterpenes of Ferula jaeschkeana*

M. M. Singh1 , A. Agnihotri1 , S. N. Garg2 , S. K. Agarwal2 , D. N. Gupta1 , G. Keshri1 , V. P. Kamboj1
  • 1Central Drug Research Institute, Lucknow-226001, India.
  • 2Central Institute of Medicinal and Aromatic Plants, Lucknow-226016, India.
* C.D.R.I. Communication no. 4145.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Of the 7 carotane sesquiterpenes of Ferula jaeschkeana Vatke evaluated, three jaeschkeanadiol esters (compounds 3, 5, and 6) showed contraceptive efficacy when administered orally on days 1-7 post coitum in rats. In ovariectomized immature female rats, however, the active compounds exhibited estrogenic activity and were devoid of antiestrogenic activity. Using a competitive protein binding assay, the compounds 3, 5, and 6 showed relative binding affinity of 0.01%, 5.75%, and 0.75% of 17β-estradiol, respectively, for rat uterine cytosol estrogen receptors.