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Planta Med 1988; 54(5): 422-425
DOI: 10.1055/s-2006-962488
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© Georg Thieme Verlag Stuttgart · New York

New 5′-Nucleotidase Inhibitors, NPF-86IA, NPF-86IB, NPF-86IIA, and NPF-86IIB from Areca catechu; Part II. Anti-Tumor Effects

Masaya Iwamoto, Toshiharu Matsuo, Keijiro Uchino, Yasuhiro Tonosaki, Akira Fukuchi
  • Central Laboratory, Nippon Flour Mills Co., Ltd., Nururnizu, Atsugi, Kanagawa 243, Japan.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

New 5′-nucleotidase inhibitors, NPF-86IA, NPF-86IB, NPF-86IIA, and NPF-86IIB were isolated from a plant origin. According to their physico-chemical properties, these compounds are polyphenolic substances. These inhibitors displayed significant therapeutic activity by intraperitoneally administration against intraperitoneally inplanted Ehrlich ascites carcinoma. In vitro, these inhibitors exhibited a moderate cytotoxicity to Ehrlich ascites carcinoma strain E, HeLa, and HL-60 cells. However, these 5′-nucleotidase inhibitors did not show an anti-tumor effects on L1210 cells in vivo and in vitro.