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Planta Med 1988; 54(5): 414-417
DOI: 10.1055/s-2006-962485
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© Georg Thieme Verlag Stuttgart · New York

Cytotoxic and Antitumor Activities of Rabdosia Diterpenoids

Tetsuro Fujita1 , 2 , Yoshio Takeda1 , Sun Han-dong3 , Yoshinori Minami4 , Teruyoshi Marunaka4 , Setsuo Takeda4 , Yuji Yamada4 , Tsuneo Togo4
  • 1Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770, Japan.
  • 2Faculty of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, 606, Japan.
  • 3Kunming Institute of Botany, The Academy of Sciences of China, Kunming, Yunnan, People's Republic of China.
  • 4Research Laboratory, Taiho Pharmaceutical Co., Ltd., Tokushima 771-01, Japan.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Twenty-four diterpenoids from the plant of the genus Rabdosia, Labiatae, were examined for the cytotoxic activity against HeLa cells and several of them were examined for their effects on the life span of mice inoculated with Ehrlich ascites carcinoma cells. All the tested compounds except for sculponeatin B (19) and isodonal (21) showed stronger in vitro activity than oridonin (11) used as positive control. The results also showed that leukamenin B (2), kambebanin (6), effusanin A (14), and sculponeatin C (20) are the most effective in vivo among the tested compounds.