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Planta Med 1988; 54(5): 381-384
DOI: 10.1055/s-2006-962476
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© Georg Thieme Verlag Stuttgart · New York

Inhibition of the Behaviour of Human Polynuclear Leukocytes by an Extract of Chrysanthemum parthenium

W. Lösche1 , E. Michel1 , S. Heptinstall2 , S. Krause1 , W. A. Groenewegen2 , G. P. Pescarmona3 , K. Thielmann1
  • 1Institute of Pathological Biochemistry, Medical Academy, Nord-häuser Str. 74, DDR-5010 Erfurt, German Democratic Republic.
  • 2Department of Medicine, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, U.K.
  • 3Department of Biology, Genetics and Medical Chemistry, University of Torino, Via Santena 5 bis, I-10126 Torino, Italy.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

Extracts of the leaves of Chrysanthemum parthenium (feverfew) inhibit the secretory activity of human blood platelets and polymorphonuclear leukocytes (PMNL) and it has been suggested that the inhibitory effect on platelets is mediated by a neutralization of cellular sulphydryl groups. The results indicate that the effect of feverfew) on PMNL behaviour may be via blockade of sulphydryl groups in the cells.