Relative Configuration and Cytotoxic Activity of Vincarubine: A Novel Bisindole Alkaloid from Vinca minor

B. Proksa; D. Uhrín; E. Grossmann; Z. Votický; J. Fuska

doi:10.1055/s-2006-962407

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Planta Med 1988; 54(3): 214-218
DOI: 10.1055/s-2006-962407

Papers

Relative Configuration and Cytotoxic Activity of Vincarubine: A Novel Bisindole Alkaloid from Vinca minor

B. Proksa¹ , D. Uhrín¹ , E. Grossmann¹ , Z. Votický¹ , J. Fuska²

¹Institute of Chemistry, Centre for Chemical Research, Slovak Academy of Sciences, 842 38 Bratislava, Czechoslovakia.
²Department of Biochemical Technology, Faculty of Chemistry, Slovak Technical University, 812 37 Bratislava, Czechoslovakia.

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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

The relative configurations of the new bisindole alkaloid vincarubine and its two O-acetyldihydro derivatives were deduced from spectral data. It has been shown that the building blocks of the molecule are vincorane and aspidospermane residues. The cytotoxic effect of vincarubine on leukemia P388 cells is also discussed.