Planta Med 1991; 57(4): 320-324
DOI: 10.1055/s-2006-960107
Papers

© Georg Thieme Verlag Stuttgart · New York

Effect of Gomisin A in the Prevention of Acute Hepatic Failure Induction

Yasuhiro Mizoguchi, Norifumi Kawada, Yuzo Ichikawa, Hiroko Tsutsui
  • Third Department of Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-machi, Abeno-ku, Osaka 545, Japan
Further Information

Publication History

1990

Publication Date:
05 January 2007 (online)

Abstract

Nearly all rats develop massive hepatic cell necrosis and die upon intravenous administration of heat-killed Propionibacterium acnes followed by a small amount of Gram-negative lipopolysaccharide 7 days later. However, when such an experimental liver disorder is induced in rats raised for 4 or more weeks on food containing 0.06% of gomisin A extracted and purified from Schizandra chinensis, the survival rate rises, histological changes of the liver improve remarkably, and splenocyte reactivity to phytohemagglutinin and pokeweed mitogen as well as splenocyte interleukin 1 productivity are retained. These results suggested the possibility that the development of acute hepatic failure may be prevented with the oral administration of gomisin A.