Subscribe to RSS
DOI: 10.1055/s-2006-959692
© Georg Thieme Verlag Stuttgart · New York
Evaluation of the Central Properties of Artemisia verlotorum 1
1 Part of this work was presented at the Xth Simpãsio Brasileiro de Plantas Medicinais, São Paulo, SP, Brazil, 1988Publication History
1992
1992
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199304/lookinside/thumbnails/10.1055-s-2006-959692-1.jpg)
Abstract
The anticonvulsive activity of the crude hydroalcoholic extract (HE) of Artemisia verlotorum (Compositae) was analysed as a part of a psychophar-macological screening of this plant. High doses of HE (2 g/kg) prevented the onset of electroshock (75 mA, 60 Hz) and pentylenetretazole-induced (75 mg/kg i.p.) convulsions and also increased the latencies to convulsions induced by 3-mercaptopropionic acid (30 mg/ kg i.p.) and pilocarpine (400 mg/kg i.p.) in mice. In addition, HE caused marked hypothermic and analgesic effects in these animals. Thus, the HE of A. verlotorum showed a protective effect against experimental convulsions elicited by various agents, as well as analgesic and hypothermic actions. These findings partially support the popular use of Artemisia verlotorum as an anti-convulsant and analgesic.
Key words
Artemisia verlotorum - hydroalcoholic extract - convulsions - pain threshold - core temperature - rat - mouse