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DOI: 10.1055/s-2006-959442
© Georg Thieme Verlag Stuttgart · New York
Biologically Active Triterpene Saponins from Bupleurum fruticosum
Publication History
1993
1993
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199402/lookinside/thumbnails/10.1055-s-2006-959442-1.jpg)
Abstract
Extracts of the root of B. fruticosum L. showed in a biological Screening hemolytical activity, hepatoprotective and phagocytosis stimiilating effects, and a specific inhibitory activity of leucine amino-peptidase. Further monitoring of the fraction with antihepatotoxic activity led to the isolation of an hepatoprotective saikosaponin identified as buddlejasaponin IV and the new malonylbuddlejasaponin IV, determined as saikogenin F-3-O-[6-O-malonyl-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl(1→3)]-β-D-fucopyranoside. The structures were elucidated on the basis of the chemical and spectroscopic data.
Key words
Bupleurum fruticosum - Apiaceae - saikosaponin - malonylsaikosaponin - antihepatotoxic activity - granulocyte phagocytosis Stimulation - leucine aminopeptidase inhibition