Planta Med 1995; 61(5): 402-405
DOI: 10.1055/s-2006-958124
Paper

© Georg Thieme Verlag Stuttgart · New York

Bellidifolin Stimulates Glucose Uptake in Rat 1 Fibroblasts and Ameliorates Hyperglycemia in Streptozotocin (STZ)-Induced Diabetic Rats

Purusotam Basnet1 , Shigetoshi Kadota, Mineo Shimizu2 , Yasumitsu Takata3 , Masashi Kobayashi3 , Tsuneo Namba1
  • 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
  • 2Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
  • 3First Department of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan
Further Information

Publication History

1995

1995

Publication Date:
04 January 2007 (online)

Abstract

Bellidifolin, isolated from Swertia japonica, was found to be a potent hypoglycemic agent in STZ-induced diabetic rats by both oral and intraperitoneal administration. Bellidifolin significantly lowered the loaded glucose level in normal as well as diabetic rats. Bellidifolin also lowered blood triglyceride levels significantly. It stimulated glucose uptake activity in Rat 1 fibroblasts expressing human insulin receptors.