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Planta Med 1997; 63(5): 465-466
DOI: 10.1055/s-2006-957736
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© Georg Thieme Verlag Stuttgart · New York

Oral Administration of a Unicellular Green Algae, Chlorealla vulgaris, Prevents Stress-Induced Ulcer

Kuniaki Tanaka1 , Akira Yamada2 , Kiyoshi Noda3 , Yukihiro Shoyama3 , Chiharu Kubo4 , Kikuo Nomoto5
  • 1Chlorella Industries Co. Ltd., 1343 Hisatomi, Chikugo City,Fukuoka 833, Japan
  • 2Department of Immunology, Kurume University School of Medicine, Kurume City, 67 Asahimachi, Kurume city, Fukuoka 830, Japan
  • 3Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan
  • 4Psychosomatic Medicine, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan
  • 5Department of Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812, Japan
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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

Oral administration of dry powder of Chlorella vulgaris (CVP) showed clear prophylactic effects in water-immersion restraint stress-induced and in cysteamine-induced peptic ulcer models, but not in Shay's rat model. Drugs that enhance the protective factors of ulcer formation are effective in the first two models. CVP may prevent ulcer formation mainly through the “immune-brain-gut” axis and protection of gastric mucosa by its own characteristics.