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Synfacts 2006(12): 1263-1263  
DOI: 10.1055/s-2006-955637
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Enantiopure α-Trifluoromethyl Amine Derivatives

Contributor(s): Mark Lautens, Yann Béthuel
F. Huguenot, T. Brigaud*
Université de Reims-Champagne-Ardenne and Université de Cergy-Pontoise-5, France
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

Organofluorine compounds and in particular trifluoromethylated amino acids, 1,2-diamines and 1,2-amino alcohols are very important scaffolds in medicinal chemistry thanks to their broad range of biological properties (see book below). In the present paper, their syntheses from chiral trifluoromethyl imines or oxazolidines using a Strecker-type reaction are described.