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Synfacts 2006(10): 1015-1015  
DOI: 10.1055/s-2006-949368
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Stimuli-Responsive Biocompatible Polymer Brush

Contributor(s): Timothy M. Swager, Changsik Song
M. H. Stenzel*, L. Zhang, W. T. S. Huck
The University of New South Wales, Sydney, Australia and Cambridge University, UK
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Publication History

Publication Date:
21 September 2006 (online)

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Significance

Stenzel et al. reported a surface-immobilized block copolymer brush that consists of poly(N-acryloyl glucosamine) (PGA) and poly-N-isopropylacrylamide (PNIPA). It was prepared via the reversible addition fragmentation chain transfer (RAFT) polymerization, one of the controlled, living radical polymerization methods. The RAFT agent was immobilized on the silicon surface, through which biocompatible PGA and temperature-responsive PNIPA were introduced successively in a living manner, i.e. with narrow distribution of molecular weights and linear increasing with monomer conversion.