Synthesis of Halipeptins A and D

K. C. Nicolaou; D. E. Lizos; D. W. Kim; D. Schlawe; R. G. de Noronha; D. A. Longbottom; M. Rodriquez; M. Bucci; G. Cirino

doi:10.1055/s-2006-949331

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Synfacts 2006(10): 0980-0980
DOI: 10.1055/s-2006-949331

Synthesis of Natural Products and Potential Drugs

Synthesis of Halipeptins A and D

Contributor(s): Philip Kocienski, Fiona Black
K. C. Nicolaou*, D. E. Lizos, D. W. Kim, D. Schlawe, R. G. de Noronha, D. A. Longbottom, M. Rodriquez, M. Bucci, G. Cirino
The Scripps Institute, La Jolla and University of California, San Diego, USA

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Publication History

Publication Date:
21 September 2006 (online)

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Significance

Halipeptins A-D are depsipeptides isolated from marine sponges. The reported syntheses of halipeptins A and D confirm the stereochemistry at C3 and C4. Biological testing revealed that both natural products, along with an oxazoline analogue, display anti-inflammatory activity. No cytotoxic activity was found despite previous reports to the contrary regarding halipeptin D.