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Synfacts 2006(7): 0694-0694
DOI: 10.1055/s-2006-941919
DOI: 10.1055/s-2006-941919
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Kinetic Resolution of Diols and Pyridyl Alcohols
C. Mazet, S. Roseblade, V. Köhler, A. Pfaltz*
University of Basel, Switzerland
Further Information
Publication History
Publication Date:
22 June 2006 (online)
Significance
This is a nice report on the kinetic resolution of racemic diols and pyridyl alcohols with the borabox ligand developed by this group. The use of this monoanionic ligand with CuCl2 gave good results with S values over 100 in many cases. Importantly, 1 gave S = 21 for trans-1,2-cyclohexanediol, compared to S = 16 obtained with Ph-box.