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Synfacts 2006(7): 0682-0682  
DOI: 10.1055/s-2006-941811
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Synthesis of Propargylamines

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
F. Colombo, M. Benaglia*, S. Orlandi, F. Usuelli, G. Celentano
Università degli Studi di Milano, Italy
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

Optically active propargylamines are valuable synthons for the construction of useful molecules. This mild protocol is a nice method for the synthesis of these compounds in their optically enriched form. Importantly, the ligand is readily synthesized in one step from commercially available materials. Cu(OTf) is used as the catalyst. Aryl- and alkyl-substituted alkynes give moderate enantioselectivities.