Sequential Cross-Coupling of gem-Dizincioalkanes

Significance

This is a new interesting approach for the construction of complex hydrocarbon frameworks. Synthetically it allows the connection of two different electrophiles by a single carbon atom. Bis(iodozincio)methane or -ethane serves here as an equivalent of the CH₂ ^2- synthon, which can react subsequently with two different electrophiles. For both steps, the optimal conditions and catalysts were found. The starting reagent, IZnCH₂ZnI, can be easily prepared by the reaction between diiodomethane and zinc metal.