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Synfacts 2006(4): 0299-0299  
DOI: 10.1055/s-2006-932027
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of a Potent Hepatitis C Virus Serine Protease Inhibitor

Contributor(s): Philip Kocienski
K. X. Chen*, F. G. Njoroge, B. Vibulbhan, A. Prongay, J. Pichardo, V. Madison, A. Buevich, T.-M. Chan
Schering-Plough Research Institute, Kenilworth, USA
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Publication History

Publication Date:
24 March 2006 (online)

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Significance

The Hepatitis C virus (HCV) has infected more than 170 million people worldwide and there is an urgent need for an effective, orally bioavailable small molecule chemotherapy. The 17-membered macrocycle D shown in the scheme emerged as an efficacious scaffold for the synthesis of potent inhibitors of HCV serine protease NS3, an essential enzyme in the replication of HCV.