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Horm Metab Res 2006; 38(4): 291-293
DOI: 10.1055/s-2006-925350
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

Co-transport of Sex Hormone-binding Globulin/SHBG with Oxytocin in Transport Vesicles of the Hypothalamo-hypophyseal System

Z.  Herbert1 , E.  Pollák2 , L.  Molnár2 , J.  D.  Caldwell3 , G.  F.  Jirikowski4
  • 1 Institute for Neurobiology, Ludwig-Maximilian-Universität Biozentrum, Munich, Germany
  • 2 Department of General Zoology, University of Pecs, Hungary
  • 3 Department of Biomedical Sciences, University of Illinois College of Medicine, Rockford, IL, USA
  • 4 Institute for Anatomy 2, Friedrich-Schiller-Universität Jena, Jena, Germany
Further Information

Publication History

Received 27 September 2005

Accepted after revision 8 December 2005

Publication Date:
15 May 2006 (online)

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Abstract

The intrinsic expression of sex hormone binding globulin (SHBG) in magnocellular hypothalamic neurons, in part co-localized with either vasopressin or oxytocin, was recently described. This study is focused on the ultrastructural localization of SHBG in the hypothalamo-neurohypophyseal pathway in rats. Immunostaining for SHBG in the hypothalamic perikarya was increased by colchicine treatment, indicating that the steroid-binding globulin is subject to rapid axoplasmic transport along with the classical posterior lobe peptides. With immunoelectron-microscopic double labeling, we found co-localization of oxytocin and sex hormone binding globulin in a portion of the large dense-core vesicles in paraventricular and supraoptic perikarya and in axonal varicosities in the median eminence and in the posterior lobe. Our observations show that SHBG is processed, transported and stored along with oxytocin suggesting that SHBG is released from nerve terminals in the posterior lobe, the median eminence and possibly the brain similarly to and in conjunction with oxytocin.

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Dr. Zsófia Herbert

Department of Neurobiology · LMU-Biozentrum

Grosshaderner Str. 2 · 82152 Planegg-Martinsried · Germany

Phone: +49(89)218074313

Fax: +49(89)218074304

Email: telapo@gmx.de

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