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Zentralbl Chir 2005; 130(5): 476-484
DOI: 10.1055/s-2005-836875
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© Georg Thieme Verlag Stuttgart · New York

Vertebroplastie - Grundlagen, Indikationen und Technik

Vertebroplasty - Basic Science, Indications and TechniqueR. Schmidt1 , M. Richter1 , W. Puhl1 , B. Cakir1
  • 1Orthopädische Klinik mit Querschnittgelähmtenzentrum der Universität Ulm
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Publication History

Publication Date:
11 October 2005 (online)

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Zusammenfassung

Einführung: Die Vertebroplastie stellt ein relativ neues Verfahren zur Behandlung von Wirbelkörperfrakturen unterschiedlicher Genese dar. Aufgrund viel versprechender Ergebnisse steigt die Anzahl der durchgeführten Interventionen stetig an. Allerdings wird auch zunehmend über teilweise schwer wiegende Komplikationen berichtet. Eine Zusammenfassung der bisherigen Erkenntnisse scheint deshalb notwendig. Methode: Anhand einer Medline-Recherche wurden wichtige Aspekte der Vertebroplastie in den Bereichen Grundlagen, Diagnostik, Indikationen, Kontraindikationen, Technik, Ergebnisse und Komplikationen zusammengestellt. Ergebnisse: Insbesondere im Bereich der Indikationsstellung, möglicher Langzeitfolgen, sowie der „idealen” Technik sind wichtige Fragen unbeantwortet, vor allem aufgrund fehlender prospektiv, randomisierter Langzeitstudien. Schlussfolgerung: Eine endgültige Bewertung des Stellenwertes der Vertebroplastie im Bereich der osteoporotischen Frakturen gegenüber der konservativen Therapie ist aktuell nicht möglich. Für die Malignome stellt die Vertebroplastie dagegen in ausgewählten Fällen eine mögliche Therapieoption dar.

Abstract

Introduction: Vertebroplasty is a relatively new procedure for the treatment of vertebral body fractures of different origin. Due to early promising results the rate of performed procedures increases constantly. Indeed an increasing number of partially severe complications are reported. A summary of the existing findings seems therefore necessary. Methods: On the basis of a medline inquiry important aspects of vertebroplasty in the fields of basic science, diagnostics, indications, contraindications, technique, results and complications were compiled. Results: Especially for the field of indications, possible longterm effects and for the “ideal” technique open questions exist, mainly due to missing prospective, randomized long-term clinical trials. Conclusions: A final assessment of the significance of vertebroplasty for osteoporotic fractures in comparison to conservative treatment is actually not possible. In contrast vertebroplasty is a therapeutical option for malignomas in selected cases.

Schlüsselwörter

Vertebroplastie - Indikationen - Technik - Komplikationen

Key words

vertebroplasty - indications - technique - complications

Literatur

  • 1 Aebli N, Krebs J, Davis G, Walton M, Williams M J, Theis J C. Fat embolism and acute hypotension during vertebroplasty: an experimental study in sheep.  Spine. 2002;  27 460-466
    CrossrefPubMedGoogle Scholar
  • 2 Aebli N, Krebs J, Schwenke D, Davis G, Theis J C. Cardiovascular changes during multiple vertebroplasty with and without vent-hole: An experimental study in sheep.  Spine. 2003;  28 1504-1512
    CrossrefPubMedGoogle Scholar
  • 3 Alvarez L, Pérez-Higueras A, Quinones D, Calvo E, Rossi R E. Vertebroplasty in the treatment of vertebral tumors: postprocedural outcome and quality of life.  Eur Spine J. 2003;  12 356-360
    CrossrefPubMedGoogle Scholar
  • 4 Amar A P, Larsen D W, Esnaashari N, Albuquerque F C, Lavine S D, Teitelbaum G P. Percutaneous transpedicular polymethylmethacrylate vertebroplasty for the treatment of spinal compression fractures.  Neurosurgery. 2001;  49 1105-1115
    PubMedGoogle Scholar
  • 5 Arinoviche R, Arriagada M, Jacobelli S. Calcitonin in acute pain due to vertebral fractures in osteoporosis.  Rev Med Chile. 1987;  115 1039-1043
    PubMedGoogle Scholar
  • 6 Baroud G, Nemes J, Heini P, Steffen T. Load shift of the intervertebral disc after a vertebroplasty: a finite-element study.  Eur Spine J. 2003;  12 421-426
    CrossrefPubMedGoogle Scholar
  • 7 Barr J D, Barr M S, Lemley T J, McCann R M. Percutaneous vertebroplasty for pain relief and spinal stabilization.  Spine. 2000;  25 923-928
    CrossrefPubMedGoogle Scholar
  • 8 Baur A, Stäbler A, Arbogast S, Duerr H R, Bartl R, Reiser M. Acute osteoporotic and neoplastic vertebral compression fractures: Fluid sign at MR imaging.  Radiology. 2002;  225 730-735
    CrossrefPubMedGoogle Scholar
  • 9 Belkoff S M, Mathis J M, Erbe E M, Fenton D C. Biomechanical evaluation of a new bone cement for use in vertebroplasty.  Spine. 2000;  25 1061-1064
    CrossrefPubMedGoogle Scholar
  • 10 Belkoff S M, Mathis J M, Jasper L E, Deramond H. The biomechanics of vertebroplasty. The effect of cement volume on mechanical behavior.  Spine. 2001;  26 1537-1541
    CrossrefPubMedGoogle Scholar
  • 11 Belkoff S M, Mathis J M, Jasper L E, Deramond H. An ex vivo biomechanical evaluation of a hydroxyapatite cement for use with vertebroplasty.  Spine. 2001;  26 1542-1546
    CrossrefPubMedGoogle Scholar
  • 12 Belkoff S M, Molloy S. Temperature measurement during polymerization of polymethylmethacrylate cement used for vertebroplasty.  Spine. 2003;  28 1555-1559
    CrossrefPubMedGoogle Scholar
  • 13 Berlemann U, Ferguson S J, Nolte L P, Heini P F. Adjacent vertebral failure after vertebroplasty. A biomechanical investigation.  J Bone Joint Surg [Br]. 2002;  84 748-752
    CrossrefPubMedGoogle Scholar
  • 14 Chen H L, Wong C S, Ho S T, Chang F L, Hsu C H, Wu C T. A lethal pulmonary embolism during percutaneous vertebroplasty.  Anesth Analg. 2002;  95 1060-1062
    PubMedGoogle Scholar
  • 15 Chung S K, Lee S H, Kim D Y, Lee H Y. Treatment of lower lumbar radiculopathy caused by osteoporotic compression fracture: the role of vertebroplasty.  J Spinal Disord Tech. 2002;  15 461-468
    CrossrefPubMedGoogle Scholar
  • 16 Cotten A, Dewatre F, Cortet B, Assaker R, Leblond D, Duquesnoy B, Chastanet P, Clarisse J. Percutaneous vertebroplasty for osteolytic metastases and myeloma: effects of the percentage of lesion filling and the leakage of methyl methacrylate at clinical follow-up.  Radiology. 1996;  200 525-530
    CrossrefPubMedGoogle Scholar
  • 17 Cuenod C A, Laredo J D, Chevret S, Hamze B, Naouri J F, Chapaux X, Bondeville J M, Tubiana J M. Acute vertebral collapse due to osteoporosis or malignancy: appearance on unenhanced and gadolinium-enhanced MR images.  Radiology. 1996;  199 541-549
    PubMedGoogle Scholar
  • 18 Dahl O E, Garvik L J, Lyberg T. Toxic effects of methylmethacrylate monomer on leukocytes and endothelial cells in vitro.  Acta Orthop Scand. 1994;  65 147-153
    CrossrefPubMedGoogle Scholar
  • 19 Danilewicz Stysiak Z. Experimental investigations on the cytotoxic nature of methyl methacrylate.  J Prosthet Dent. 1980;  44 13-16
    PubMedGoogle Scholar
  • 20 Dean J R, Ison K T, Gishen P. The strengthening effect of percutaneous vertebroplasty.  Clin Radiol. 2000;  55 471-476
    CrossrefPubMedGoogle Scholar
  • 21 Deichmann W. Toxicity of methyl, ethyl and n-butyl methacrylate.  J Indust Hyg Toxicol. 1941;  23 343-351
    PubMedGoogle Scholar
  • 22 Deramond H, Depriester C, Galibert P, Le Gars D. Percutaneous vertebroplasty with polymethylmethacrylate. Technique, indications, and results.  Radiol Clin North Am. 1998;  36 533-546
    CrossrefPubMedGoogle Scholar
  • 23 Deramond H, Wright N T, Belkoff S M. Temperature elevation caused by bone cement polymerization during vertebroplasty.  Bone. 1999;  25 17s-21s
    CrossrefPubMedGoogle Scholar
  • 24 Diamond T H, Champion B, Clark W A. Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy.  Am J Med. 2003;  114 257-265
    CrossrefPubMedGoogle Scholar
  • 25 Dudeney S, Lieberman I H, Reinhardt M K, Hussein M. Kyphoplasty in the treatment of osteolytic vertebral compression fractures as a result of multiple myeloma.  J Clin Oncol. 2002;  20 2382-2387
    Google Scholar
  • 26 DVO .Leitlinien Osteoporose des Dachverbandes Osteologie. 5: 2003
    Google Scholar
  • 27 Ensrud K E, Black D M, Harris F, Ettinger B, Cummings S R. The Fracture Intervention Trial Research Group . Correlates of kyphosis in older women.  J Am Geriatr Soc. 1997;  45 682-687
    PubMedGoogle Scholar
  • 28 Fourney D R, Schomer D F, Nader R, Chlan Fourney J, Suki D, Ahrar K, Rhines L D, Gokaslan Z L. Percutaneous vertebroplasty and kyphoplasty for painful vertebral body fractures in cancer patients.  J Neurosurg. 2003;  98 21-30
    Google Scholar
  • 29 Galibert P, Deramond H, Rosat P, Le Gars D. Note preliminaire sur le traitement des angiomes vertebraux par vertebroplastie acrylique percutanee.  Neurochirurgie. 1987;  33 166-168
    PubMedGoogle Scholar
  • 30 Gangi A, Kastler B A, Dietemann J L. Percutaneous vertebroplasty guided by a combination of CT and fluoroscopy.  AJNR Am J Neuroradiol. 1994;  15 83-86
    PubMedGoogle Scholar
  • 31 Garfin S R, Yuan H A, Reiley M A. New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures.  Spine. 2001;  26 1511-1515
    Google Scholar
  • 32 Gaughen J R, Jensen M E, Schweickert P A, Kaufmann T J, Marx W F, Kallmes D F. Relevance of antecedent venography in percutaneous vertebroplasty for the treatment of osteoporotic compression fractures.  AJNR Am J Neuroradiol. 2002;  23 594-600
    PubMedGoogle Scholar
  • 33 Grados F, Depriester C, Cayrolle G, Hardy N, Deramond H, Fardellone P. Long-term observations of vertebral osteoporotic fractures treated by percutaneous vertebroplasty.  Rheumatology (Oxford). 2000;  39 1410-1414
    CrossrefPubMedGoogle Scholar
  • 34 Harrington K D. Major neurological complications following percutaneous vertebroplasty with polymethylmethacrylate: a case report.  J Bone Joint Surg [Am]. 2001;  83 1070-1073
    PubMedGoogle Scholar
  • 35 Hasegawa K, Homma T, Uchiyama S, Takahashi H E. Vertebral pseudarthrosis in the osteoporotic spine.  Spine. 1998;  23 2201-2206
    CrossrefPubMedGoogle Scholar
  • 36 Heggeness M H. Spine fracture with neurological deficit in osteoporosis.  Osteoporos Int. 1993;  3 215-221
    PubMedGoogle Scholar
  • 37 Heini P F, Berlemann U, Kaufmann M, Lippuner K, Frankhauser C, Landuyt P van. Augmentation of mechanical properties in osteoporotic vertebral bones - a biomechanical investigation of vertebroplasty efficacy with different bone cements.  Eur Spine J. 2001;  10 164-171
    CrossrefPubMedGoogle Scholar
  • 38 Heini P F, Orler R. Vertebroplastik bei hochgradiger Osteoporose: Technik und Erfahrung mit plurisegmentalen Injektionen.  Orthopäde. 2004;  33 22-30
    CrossrefPubMedGoogle Scholar
  • 39 Higgins K B, Harten R D, Langrana N A, Reiter M F. Biomechancial effects of unipedicular vertebroplasty on intact vertebrae.  Spine. 2003;  28 1540-1548
    CrossrefPubMedGoogle Scholar
  • 40 Hitchon P W, Goel V, Drake J, Taggard D, Brenton M, Rogge T, Torner J C. Comparison of the biomechanics of hydroxyapatite and polymethylmethacrylate vertebroplasty in cadaveric spinal compression fracture model.  J Neurosurg. 2001;  95 215-220
    PubMedGoogle Scholar
  • 41 Jang J-S, Kim D-Y, Lee S-H. Efficacy of percutaneous vertebroplasty in the treatment of intravertebral pseudarthrosis associated with noninfected avascular necrosis of the vertebral body.  Spine. 2003;  28 1588-1592
    CrossrefPubMedGoogle Scholar
  • 42 Jang J S, Lee S H, Jung S K. Pulmonary embolism of polymethylmethacrylate after percutaneous vertebroplasty: a report of three cases.  Spine. 2002;  27 E416-E418
    CrossrefPubMedGoogle Scholar
  • 43 Jarvik J G, Kallmes D F, Sohail K M. Vertebroplasty: Learning more, but not enough.  Spine. 2003;  28 1487-1489
    CrossrefPubMedGoogle Scholar
  • 44 Jensen M E, Evans A J, Mathis J M, Kallmes D F, Cloft H J, Dion J E. Percutaneous polymethylmethacrylate vertebroplasty in the treatment of osteoporotic vertebral body compression fractures: technical aspects.  AJNR Am J Neuroradiol. 1997;  18 1897-1904
    PubMedGoogle Scholar
  • 45 Kado D M, Browner W S, Palermo L, Nevitt M C, Genant H K, Cummings S R. Study of Osteoporotic Fractures Research Group . Vertebral fractures and mortality in older women: a prospective study.  Arch Intern Med. 1999;  159 1215-1220
    Google Scholar
  • 46 Kaufmann T J, Jensen M E, Schweickert P A, Marx W F, Kallmes D F. Age of fracture and clinical outcomes of percutaneous vertebroplasty.  AJNR Am J Neuroradiol. 2001;  22 1860-1863
    PubMedGoogle Scholar
  • 47 Kim A K, Jensen M E, Dion J E, Schweickert P A, Kaufmann T J, Kallmes D F. Unilateral transpedicular percutaneous vertebroplasty: initial experience.  Radiology. 2002;  222 737-741
    CrossrefPubMedGoogle Scholar
  • 48 Kochan J P. Percutaneous vertebroplasty and kyphoplasty. Online article: www.emedicine.com 2002; 3
    Google Scholar
  • 49 Lane J I, Maus T P, Wald J T, Thielen K R, Bobra S, Luetmer P H. Intravertebral clefts opacified during vertebroplasty: pathogenesis, technical implications, and prognostic significance.  AJNR Am J Neuroradiol. 2002;  23 1642-1646
    PubMedGoogle Scholar
  • 50 Laredo J D, Assouline E, Gelbert F, Wybier M, Merland J J, Tubiana J M. Vertebral hemangiomas: fat content as a sign of aggressiveness.  Radiology. 1990;  177 467-472
    PubMedGoogle Scholar
  • 51 Laredo J D, Lakhdari K, Bellaiche L, Hamze B, Jamklewicz P, Tubiana J M. Acute vertebral collapse: CT findings in benign and malignant nontraumatic cases.  Radiology. 1995;  194 41-48
    CrossrefPubMedGoogle Scholar
  • 52 Laredo J D, Reizine D, Bard M, Merland J J. Vertebral hemangiomas: radiologic evaluation.  Radiology. 1986;  161 183-189
    PubMedGoogle Scholar
  • 53 Ledlie J T, Renfro M. Balloon kyphoplasty: one-year outcomes in vertebral body height restoration, chronic pain, and activity levels.  J Neurosurg. 2003;  98 36-42
    Google Scholar
  • 54 Lee B J, Lee S R, Yoo T Y. Paraplegia as a complication of percutaneous vertebroplasty with polymethylmethacrylate: a case report.  Spine. 2002;  27 E419-E422
    CrossrefPubMedGoogle Scholar
  • 55 Leidig Bruckner G, Minne H W, Schlaich C, Wagner G, Scheidt Nave C, Bruckner T, Gebest H J, Ziegler R. Clinical grading of spinal osteoporosis: quality of life components and spinal deformity in women with chronic low back pain and women with vertebral osteoporosis.  J Bone Miner Res. 1997;  12 663-675
    PubMedGoogle Scholar
  • 56 Levine S A, Perin L A, Hayes D, Hayes W S. An evidence-based evaluation of percutaneous vertebroplasty.  Manag Care. 2000;  9 56-60
    PubMedGoogle Scholar
  • 57 Lieberman I H, Dudeney S, Reinhardt M K, Bell G. Initial outcome and efficacy of “kyphoplasty” in the treatment of painful osteoporotic vertebral compression fractures.  Spine. 2001;  26 1631-1638
    CrossrefPubMedGoogle Scholar
  • 58 Liebschner M A, Rosenberg W S, Keaveny T M. Effects of bone cement volume and distribution on vertebral stiffness after vertebroplasty.  Spine. 2001;  26 1547-1554
    CrossrefPubMedGoogle Scholar
  • 59 Lindsay R, Silverman S L, Cooper C, Hanley D A, Barton I, Broy S B, Licata A, Benhamou L, Geusens P, Flowers K, Stracke H, Seeman E. Risk of new vertebral fracture in the year following a fracture.  JAMA. 2001;  285 320-323
    CrossrefPubMedGoogle Scholar
  • 60 Lyritis G P, Mayasis B, Tsakalakos N, Lambropoulos A, Gazi S, Karachalios T, Tsekoura M, Yiatzides A. The natural history of the osteoporotic vertebral fracture.  Clin Rheumatol. 1989;  8 (Suppl 2) 66-69
    CrossrefPubMedGoogle Scholar
  • 61 Malghem J, Vande Berg B, Clapuyt P, Maldague B. Intravertebral vacuum cleft: changes in content after supine positioning.  Radiology. 1993;  187 483-487
    PubMedGoogle Scholar
  • 62 Martin J B, Jean B, Sugiu K, San Millan Ruiz D, Piotin M, Murphy K, Rufenacht B, Muster M, Rufenacht D A. Vertebroplasty: clinical experience and follow-up results.  Bone. 1999;  25 11s-15s
    CrossrefPubMedGoogle Scholar
  • 63 Mathis J M. Vertebroplasty for vertebral fractures with intravertebral clefts.  AJNR Am J Neuroradiol. 2002;  23 1619-1620
    PubMedGoogle Scholar
  • 64 Maynard A S, Jensen M E, Schweickert P A, Marx W F, Short J G, Kallmes D F. Value of bone scan imaging in predicting pain relief from percutaneous vertebroplasty in osteoporotic vertebral fractures.  AJNR Am J Neuroradiol. 2000;  21 1807-1812
    PubMedGoogle Scholar
  • 65 McGraw J K, Heatwole E V, Strnad B T, Silber J S, Patzilk S B, Boorstein J M. Predictive value of intraosseous venography before percutaneous vertebroplasty.  J Vasc Interv Radiol. 2002;  13 149-153
    CrossrefPubMedGoogle Scholar
  • 66 McGraw J K, Lippert J A, Minkus K D, Rami P M, Davis T M, Budzik R F. Prospective evaluation of pain relief in 100 patients undergoing percutaneous vertebroplasty: results and follow-up.  J Vasc Interv Radiol. 2002;  13 883-886
    CrossrefPubMedGoogle Scholar
  • 67 McKiernan F, Jensen R, Faciszewski T. The dynamic mobility of vertebral compression fractures.  J Bone Miner Res. 2003;  18 24-29
    PubMedGoogle Scholar
  • 68 Molloy S, Mathis J M, Belkoff S M. The effect of vertebral body percentage fill on mechanical behaviour during percutaneous vertebroplasty.  Spine. 2003;  28 1549-1554
    CrossrefPubMedGoogle Scholar
  • 69 Moreland D B, Landi M K, Grand W. Vertebroplasty: techniques to avoid compliations.  Spine J. 2001;  1 66-71
    CrossrefPubMedGoogle Scholar
  • 70 O'Brien J P, Sims J T, Evans A J. Vertebroplasty in patients with severe vertebral compression fractures: a technical report.  AJNR Am J Neuroradiol. 2000;  21 1555-1558
    PubMedGoogle Scholar
  • 71 Padovani B, Kasriel O, Brunner P, Peretti Viton P. Pulmonary embolism caused by acrylic cement: a rare complication of percutaneous vertebroplasty.  AJNR Am J Neuroradiol. 1999;  20 375-377
    PubMedGoogle Scholar
  • 72 Phillips F M, Ho E, Campbell-Hupp R N, McNally T, Wetzel F T, Gupta P. Early Radiographic and clinical results of balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures.  Spine. 2003;  28 2260-2267
    CrossrefPubMedGoogle Scholar
  • 73 Phillips F M, Todd Wetzel F, Lieberman I, Campbell Hupp M. An in vivo comparison of the potential for extravertebral cement leak after vertebroplasty and kyphoplasty.  Spine. 2002;  27 2173-2178
    CrossrefPubMedGoogle Scholar
  • 74 Ratliff J, Nguyen T, Heiss J. Root and spinal cord compression from methylmethacrylate vertebroplasty.  Spine. 2001;  26 E300-E302
    CrossrefPubMedGoogle Scholar
  • 75 Riggs B L, Melton L J. The worldwide problem of osteoporosis: insights afforded by epidemiology.  Bone. 1995;  17 505s-511s
    CrossrefPubMedGoogle Scholar
  • 76 Roemer F W, Bohndorf K. Long-term osseous sequelae after acute trauma of the knee joint evaluated by MRI.  Skeletal Radiol. 2002;  31 615-623
    CrossrefPubMedGoogle Scholar
  • 77 Ross P D, Ettinger B, Davis J W, Melton L J, Wasnich R D. Evaluation of adverse health outcomes associated with vertebral fractures.  Osteoporos Int. 1991;  1 134-140
    CrossrefPubMedGoogle Scholar
  • 78 Ryu K S, Park C K, Kim M C, Kang J K. Dose-dependent epidural leakage of polymethylmethacrylate after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures.  J Neurosurg. 2002;  96 56-61
    PubMedGoogle Scholar
  • 79 San Millan Ruiz D, Burkhardt K, Jean B, Muster M, Martin J B, Bouvier J, Fasel J H, Rufenacht D A, Kurt A M. Pathology findings with acrylic implants.  Bone. 1999;  25 85S-90S
    CrossrefPubMedGoogle Scholar
  • 80 Scroop R, Eskridge J, Britz G W. Paradoxical cerebral arterial embolization of cement during intraoperative vertebroplasty: case report.  AJNR Am J Neuroradiol. 2002;  23 868-870
    PubMedGoogle Scholar
  • 81 Shapiro S, Abel T, Purvines S. Surgical removal of epidural and intradural polymethylmethacrylate extravasation complicating percutaneous vertebroplasty for an osteoporotic lumbar compression fracture. Case report.  J Neurosurg. 2003;  98 90-92
    PubMedGoogle Scholar
  • 82 Spuentrup E, Buecker A, Adam G, Vaals J J van, Guenther R W. Diffusion-weighted MR imaging for differentiation of benign fracture edema and tumor infiltration of the vertebral body.  AJR Am J Roentgenol. 2001;  176 351-358
    CrossrefPubMedGoogle Scholar
  • 83 Theodorou D J. The intravertebral vacuum cleft sign.  Radiology. 2001;  221 787-788
    CrossrefPubMedGoogle Scholar
  • 84 Togawa D, Bauer T W, Lieberman I H, Takikawa S. Histologic evaluation of human vertebral bodies after vertebral augmentation with polymethyl methacrylate.  Spine. 2003;  28 1521-1527
    CrossrefPubMedGoogle Scholar
  • 85 Tohmeh A G, Mathis J M, Fenton D C, Levine A M, Belkoff S M. Biomechanical efficacy of unipedicular versus bipedicular vertebroplasty for the management of osteoporotic compression fractures.  Spine. 1999;  24 1772-1776
    CrossrefPubMedGoogle Scholar
  • 86 Tozzi P, Abdelmoumene Y, Corno A F, Gersbach P A, Hoogewoud H M, Segesser L K. Management of pulmonary embolism during acrylic vertebroplasty.  Ann Thorac Surg. 2002;  74 1706-1708
    CrossrefPubMedGoogle Scholar
  • 87 Uppin A A, Hirsch J A, Centenera L V, Pfiefer B A, Pazianos A G, Choi I S. Occurrence of new vertebral body fracture after percutaneous vertebroplasty in patients with osteoporosis.  Radiology. 2003;  226 119-124
    CrossrefPubMedGoogle Scholar
  • 88 Vasconcelos C, Gailloud P, Beauchamp N J, Heck D V, Murphy K J. Is percutaneous vertebroplasty without pretreatment venography safe? Evaluation of 205 consecutives procedures.  AJNR Am J Neuroradiol. 2002;  23 913-917
    PubMedGoogle Scholar
  • 89 Wasnich R D. Vertebral fracture epidemiology.  Bone. 1996;  18 179S-183S
    CrossrefPubMedGoogle Scholar
  • 90 Watts N B, Harris S T, Genant H K. Treatment of painful osteoporotic vertebral fractures with percutaneous vertebroplasty or kyphoplasty.  Osteoporos Int. 2001;  12 429-437
    CrossrefPubMedGoogle Scholar
  • 91 Weill A, Chiras J, Simon J M, Rose M, Sola Martinez T, Enkaooua E. Spinal metastases: indications for and results of percutaneous injection of acrylic cement.  Radiology. 1996;  199 241-247
    PubMedGoogle Scholar
  • 92 Wenger M, Markwalder T M. Cement leakage and the need for prophylactic fenestration of the spinal canal during vertebroplasty.  J Bone Joint Surg [Am]. 2002;  84 689
    PubMedGoogle Scholar
  • 93 Wenger M, Markwalder T M. Surgically controlled, transpedicular methyl methacrylate vertebroplasty with fluoroscopic guidance.  Acta Neurochir (Wien). 1999;  141 625-631
    CrossrefPubMedGoogle Scholar
  • 94 Wilson D R, Myers E R, Mathis J M, Scribner R M, Conta J A, Reiley M A, Talmadge K D, Hayes W C. Effect of augmentation on the mechanics of vertebral wedge fractures.  Spine. 2000;  25 158-165
    Google Scholar
  • 95 Wong W, Reiley M A, Garfin S. Vertebroplasty/kyphoplasty.  Journal of Women's Imaging. 2000;  2 117-124
    PubMedGoogle Scholar
  • 96 Yeom J S, Kim W J, Choy W S, Lee C K, Chang B S, Kang J W. Leakage of cement in percutaneous transpedicular vertebroplasty for painful osteoporotic compression fractures.  J Bone Joint Surg [Br]. 2003;  85 83-89
    CrossrefPubMedGoogle Scholar
  • 97 Yuh W TC, Mayr N A, Petropoulou K, Beall D P. MR fluid sign in osteoporotic vertebral fracture.  Radiology. 2003;  227 905
    PubMedGoogle Scholar
  • 98 Zoarski G H, Snow P, Olan W J, Stallmeyer M J, Dick B W, Hebel J R, De Deyne M. Percutaneous vertebroplasty for osteoporotic compression fractures: quantitative prospective evaluation of long-term outcomes.  J Vasc Interv Radiol. 2002;  13 139-148
    CrossrefPubMedGoogle Scholar

Dr. med. R. Schmidt

Orthopädische Klinik mit Querschnittgelähmtenzentrum der Universität Ulm

Oberer Eselsberg 45

89081 Ulm

Phone: 07 31/1 77 51 37

Fax: 07 31/1 77 11 18

Email: rene.schmidt@gmx.de

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