Viszeralchirurgie 2005; 40(1): 37-44
DOI: 10.1055/s-2005-836314
Originalarbeit

© Georg Thieme Verlag Stuttgart · New York

Das kavernöse Leberhämangiom: Rationale Diagnostik und therapeutisches Vorgehen

Cavernous Liver Hemangioma: Rational Diagnostics and Therapeutic ApproachH.-J. Gassel1 , I. Klein1 , U. Steger1 , M. Simon1 , A. Thiede1
  • 1Chirurgische Universitätsklinik und Poliklinik, Würzburg
Further Information

Publication History

Publication Date:
02 March 2005 (online)

Zusammenfassung

Das Leberhämangiom ist weltweit der häufigste Lebertumor. Aufgrund der hohen Inzidenz ist der Krankheitswert zweifelhaft und die Frage der Therapienotwendigkeit zu diskutieren. Das klinische Krankheitsbild ist uncharakteristisch und häufig nicht eindeutig zuzuordnen. Spontanrupturen sind äußerst selten. Neben Sonographie als Primärdiagnostik stehen heute die Kontrastmittel-CT sowie die Magnetresonanztomographie im Vordergrund. Szintigraphie und Angiographie werden bei unklaren Befunden hinzugezogen. Mit bildgebenden Verfahren ist ein Hämangiom in über 95 % der Fälle sicher zu diagnostizieren. Nur bei unklaren Fällen sollte eine Explorativlaparoskopie oder -tomie mit Histologiesicherung vorgenommen werden. Eine transkutane Blindpunktion ist bei Hämangiomverdacht kontraindiziert. Außer in Fällen diagnostischer Unsicherheit besteht eine Operationsindikation heute nur noch bei komplizierenden Verläufen mit Kompressionserscheinungen, raschem Wachstum oder individuellen Besonderheiten. Das Management der Spontanruptur besteht im Allgemeinen in der primären Embolisation gefolgt von elektiver Operation.

Abstract

Hemangiomas are the most common benign liver tumours. Due to the high incidence the pathological value of this tumour is doubtful and the necessity for specific treatment requires further discussion. Spontaneous ruptures of liverhemangiomas are exceptional. Using modern imaging procedures, hemangiomas of the liver can be diagnosed safely in more than 95 %. Ultrasound is the first line diagnostic means followed by CT scan and MRI imaging. Only in cases of diagnostic uncertainties, an explorative laparoscopy or laparotomy should be considered in order to obtain a histological diagnosis. Transcutaneous biopsies are contraindicated in suspected hemangiomas. An indication for surgical treatment is only given in cases of diagnostic uncertainties, in rapidly growing tumors or in complicated cases, e. g. compression of vessels or viscera. A ruptured hemangioma can be treated by embolization and subsequent surgery in many, but not all cases.

Literatur

  • 1 Lise M, Feltrin G, Da Pian P P, Miotto D, Pilati P L, Rubaltelli L. et al . Giant cavernous hemangiomas: diagnosis and surgical strategies.  World J Surg. 1992;  16 516-520
  • 2 Iwatsuki S, Todo S, Starzl T E. Excisional therapy for benign hepatic lesions.  Surg Gynecol Obstet. 1990;  171 240-246
  • 3 Paré A. Formaciones vasculares visibles en la superficie hepática. Paris 1570; 1510-1590
  • 4 Frerichs F T. A clinical treatise on Disease of the Liver. Vol. 2. Translated by C. Murchinson. New Sydenham Society, London 1861
  • 5 Tung G A, Vaccaro J P, Cronan J J, Rogg J M. Cavernous hemangioma of the liver: pathologic correlation with high- field MR imaging.  AJR Am J Roentgenol. 1994;  162 1113-1117
  • 6 Karhunen P J. Benign hepatic tumours and tumour like conditions in men.  J Clin Pathol. 1986;  39 183-188
  • 7 Baer H U, Schweizer W, Gertsch P, Blumgart L H. Klinik, Diagnostik und Therapie von „großen” Leberhämangiomen.  Helv Chir Acta. 1987;  54 387-389
  • 8 Kawarada Y, Mizumoto R. Surgical treatment of giant hemangioma of the liver.  Am J Surg. 1984;  148 287-291
  • 9 Ochsner J L, Halpert B. Cavernous hemangioma of the liver.  Surgery. 1958;  43 7-582
  • 10 Trastek V F, van Heerden J A, Sheedy P F, Adson M A. Cavernous hemangiomas of the liver: resect or observe?.  Am J Surg. 1983;  145 49-53
  • 11 Craig J R, Peters R L. Tumors of the liver and intrahepatic bile ducts. Atlas of tumor pathology. Washington, DC: Armed Forces institute of Pathology 1989
  • 12 Bannash P, Zerban H. Pathobiology of tumors in laboratory animals. 2nd ed. International Agency for Research on Cancer, Lyon 1990
  • 13 Chen M F. Hepatic resection for benign tumours of the liver.  J Gastroenterol Hepatol. 2000;  15 587-592
  • 14 Takahashi T, Kuwao S, Katagiri H, Kakita A. Multiple liver hemangiomas enlargement during long-term steroid therapy for myasthenia gravis.  Dig Dis Sci. 1998;  43 1553-1556
  • 15 Farber E, Sarma D S. Hepatocarcinogenesis: a dynamic cellular perspective.  Lab Invest. 1987;  56 4-22
  • 16 Chen M F. Hepatic resection for benign tumours of the liver.  J Gastroenterol Hepatol. 2000;  15 587-592
  • 17 Ishak K G, Rabin L. Benign tumors of the liver.  Med Clin North Am. 1975;  59 995-1013
  • 18 Popescu I, Ciurea S, Brasoveanu V, Hrehoret D, Boeti P, Georgescu S. et al . Liver hemangioma revisited: current surgical indications, technical aspects, results.  Hepatogastroenterology. 2001;  48 770-776
  • 19 Barg-Hock H, Weimann A, Grote R, Repp H, Klempnauer J, Pichlmayr R. [Symptomatic compression of the vena cava caused by a small liver hemangioma].  Dtsch Med Wochenschr. 1994;  119 544-547
  • 20 Weiler H, Frohlich E, Hackelsberger A, Fruhmorgen P, Treichel J. [Cavernous liver hemangioma with arterio-portal fistula].  Z Gastroenterol. 1992;  30 329-332
  • 21 Gonzales E M, Diaz J CM, Moreno A. Diagnosis and management of haemangiomas of the liver. In: Poston GJ, Blumgart LH (eds). Surgical management of hepatobilary and pancreatic disorders. Taylor and Francis, London, New York 2003; 173-192
  • 22 Creasy G W, Flickinger F, Kraus R E. Maternal liver hemangioma in pregnancy as an incidental finding.  Obstet Gynecol. 1985;  66 (Suppl 3) 10-13
  • 23 Graham E, Cohen A W, Soulen M, Faye R. Symptomatic liver hemangioma with intra-tumor hemorrhage treated by angiography and embolization during pregnancy.  Obstet Gynecol. 1993;  81 813-816
  • 24 Itai Y. Liver haemangioma and pregnancy.  Lancet. 1996;  347 1693-1694
  • 25 Belli L, De Carlis L, Beati C, Rondinara G, Sansalone V, Brambilla G. Surgical treatment of symptomatic giant hemangiomas of the liver.  Surg Gynecol Obstet. 1992;  174 474-478
  • 26 Itai Y, Ohtomo K, Araki T, Furui S, Iio M, Atomi Y. Computed tomography and sonography of cavernous hemangioma of the liver.  AJR Am J Roentgenol. 1983;  141 315-320
  • 27 Freeny P C, Marks W M. Hepatic hemangioma: dynamic bolus CT.  AJR Am J Roentgenol. 1986;  147 711-719
  • 28 Johnson C M, Sheedy P F, Stanson A W, Stephens D H, Hattery R R, Adson M A. Computed tomography and angiography of cavernous hemangiomas of the liver.  Radiology. 1981;  138 115-121
  • 29 Nelson R C, Chezmar J L. Diagnostic approach to hepatic hemangiomas.  Radiology. 1990;  176 11-13
  • 30 Krause T, Hauenstein K, Studier-Fischer B, Schuemichen C, Moser E. Improved evaluation of technetium-99m-red blood cell SPECT in hemangioma of the liver.  J Nucl Med. 1993;  34 375-380
  • 31 Birnbaum B A, Weinreb J C, Megibow A J, Sanger J J, Lubat E, Kanamuller H. et al . Definitive diagnosis of hepatic hemangiomas: MR imaging versus 99mTc-labeled red blood cell SPECT.  Radiology. 1990;  176 95-101
  • 32 Choi B I, Shin Y M, Chung J W, Kim S H, Park J H, Han M C. MR findings of hepatic cavernous hemangioma after intraarterial infusion if iodized oil.  Abdom Imaging. 1994;  19 507-511
  • 33 Sigal R, Lanir A, Atlan H, Naschitz J E, Simon J S, Enat R. et al . Nuclear magnetic resonance imaging of liver hemangiomas.  J Nucl Med. 1985;  26 1117-1122
  • 34 Stark D D, Felder R C, Wittenberg J, Saini S, Butch R J, White M E. et al . Magnetic resonance imaging of cavernous hemangioma of the liver: tissue-specific characterization.  AJR Am J Roentgenol. 1985;  145 213-222
  • 35 Kato M, Sugawara I, Okada A, Kuwata K, Satani M. Hemangioma of the liver. Diagnosis with combined use of laparoscopy and hepatic arteriography.  Am J Surg. 1975;  129 698-703
  • 36 Terkivatan T, Vrijland W W, Den Hoed P T, De Man R A, Hussain S M, Tilanus H W. et al . Size of lesion is not a criterion for resection during management of giant liver haemangioma.  Br J Surg. 2002;  89 1240-1244
  • 37 Schwartz S I, Husser W C. Cavernous hemangioma of the liver. A single institution report of 16 resections.  Ann Surg. 1987;  205 456-465
  • 38 Trastek V F, van Heerden J A, Sheedy P F, Adson M A. Cavernous hemangiomas of the liver: resect or observe?.  Am J Surg. 1983;  145 49-53
  • 39 Farges O, Daradkeh S, Bismuth H. Cavernous hemangiomas of the liver: are there any indications for resection?.  World J Surg. 1995;  19 19-24
  • 40 Yamamoto T, Kawarada Y, Yano T, Noguchi T, Mizumoto R. Spontaneous rupture of hemangioma of the liver: treatment with transcatheter hepatic arterial embolization.  Am J Gastroenterol. 1991;  86 1645-1649
  • 41 Farges O, Daradkeh S, Bismuth H. Cavernous hemangiomas of the liver: are there any indications for resection?.  World J Surg. 1995;  19 19-24
  • 42 Charny C K, Jarnagin W R, Schwartz L H, Frommeyer H S, DeMatteo R P, Fong Y. et al . Management of 155 patients with benign liver tumours.  Br J Surg. 2001;  88 808-813
  • 43 Moreno E A, Del Pozo R M, Vicente C M, Abellan A J. Indications for surgery in the treatment of hepatic hemangioma.  Hepatogastroenterology. 1996;  43 422-426
  • 44 Weimann A, Ringe B, Klempnauer J, Lamesch P, Gratz K F, Prokop M. et al . Benign liver tumors: differential diagnosis and indication for surgery.  World J Surg. 1997;  21 983-991
  • 45 Pietrabissa A, Giulianotti P, Campatelli A, Di Candio G, Farina F, Signori S. et al . Management and follow-up of 78 giant haemangiomas of the liver.  Br J Surg. 1996;  83 915-918
  • 46 Popescu I, Ciurea S, Brasoveanu V, Hrehoret D, Boeti P, Georgescu S. et al . Liver hemangioma revisited: current surgical indications, technical aspects, results.  Hepatogastroenterology. 2001;  48 770-776
  • 47 Yamagata M, Kanematsu T, Matsumata T, Utsunomiya T, Ikeda Y, Sugimachi K. Management of haemangioma of the liver: comparison of results between surgery and observation.  Br J Surg. 1991;  78 1223-1225
  • 48 Tsai M K, Lee P H, Tung B S, Yu S C, Lee C S, Wei T C. Experiences in surgical management of cavernous hemangioma of the liver.  Hepatogastroenterology. 1995;  42 988-992
  • 49 Schwartz S I, Husser W C. Cavernous hemangioma of the liver. A single institution report of 16 resections.  Ann Surg. 1987;  205 456-465
  • 50 Brouwers M A, Peeters P M, de Jong K P, Haagsma E B, Klompmaker I J, Bijleveld C M. et al . Surgical treatment of giant haemangioma of the liver.  Br J Surg. 1997;  84 314-316
  • 51 Starzl T E, Koep L J, Weil R. Excisional treatment of cavernous hemangioma of the liver.  Ann Surg. 1980;  192 25-27
  • 52 Belghiti J, Pateron D, Panis Y, Vilgrain V, Flejou J F, Benhamou J P. et al . Resection of presumed benign liver tumors.  Br J Surg. 1993;  80 380-383
  • 53 Gilon D, Slater P E, Benbassat J. Can decision analysis help in the management of giant hemangioma of the liver?.  J Clin Gastroenterol. 1991;  13 255-258
  • 54 Nichols F C, van Heerden J A, Weiland L H. Benign liver tumors.  Surg Clin North Am. 1989;  69 297-314
  • 55 Ozden I, Emre A, Alper A, Tunaci M, Acarli K, Bilge O. et al . Long-term results of surgery for liver hemangiomas.  Arch Surg. 2000;  135 978-981
  • 56 Baer H U, Dennison A R, Mouton W, Stain S C, Zimmermann A, Blumgart L H. Enucleation of giant hemangiomas of the liver. Technical and pathologic aspects of a neglected procedure.  Ann Surg. 1992;  216 673-676
  • 57 Vishnevsky V A, Mohan V S, Pomelov V S, Todua F I, Guseinov E K. Surgical treatment of giant cavernous hemangioma liver.  HPB Surg. 1991;  4 69-78
  • 58 Belli L, De Carlis L, Beati C, Rondinara G, Sansalone V, Brambilla G. Surgical treatment of symptomatic giant hemangiomas of the liver.  Surg Gynecol Obstet. 1992;  174 474-478
  • 59 Bornman P C, Terblanche J, Blumgart R L, Jones E P, Pickard H, Kalvaria I. Giant hepatic hemangiomas: diagnostic and therapeutic dilemmas.  Surgery. 1987;  101 445-449
  • 60 Biswal B M, Sandhu M, Lal P, Bal C S. Role of radiotherapy in cavernous hemangioma liver.  Indian J Gastroenterol. 1995;  14 95-98
  • 61 Gaspar L, Mascarenhas F, da Costa M S, Dias J S, Afonso J G, Silvestre M E. Radiation therapy in the unresectable cavernous hemangioma of the liver.  Radiother Oncol. 1993;  29 45-50
  • 62 Yamamoto T, Kawarada Y, Yano T, Noguchi T, Mizumoto R. Spontaneous rupture of hemangioma of the liver: treatment with transcatheter hepatic arterial embolization.  Am J Gastroenterol. 1991;  86 1645-1649
  • 63 Panis Y, Fagniez P L, Cherqui D, Roche A, Schaal J C, Jaeck D. Successful arterial embolisation of giant liver haemangioma. Report of a case with five-year computed tomography follow-up.  HPB Surg. 1993;  7 141-146
  • 64 Graham E, Cohen A W, Soulen M, Faye R. Symptomatic liver hemangioma with intra-tumor hemorrhage treated by angiography and embolization during pregnancy.  Obstet Gynecol. 1993;  81 813-816
  • 65 Huang X Q, Huang Z Q, Duan W D, Zhou N X, Feng Y Q. Severe biliary complications after hepatic artery embolization.  World J Gastroenterol. 2002;  8 119-123
  • 66 Reading N G, Forbes A, Nunnerley H B, Williams R. Hepatic haemangioma: a critical review of diagnosis and management.  Q J Med. 1988;  67 431-445
  • 67 Allison D J, Jordan H, Hennessy O. Therapeutic embolisation of the hepatic artery: a review of 75 procedures.  Lancet. 1985;  1 595-599
  • 68 Riesener K P, Treutner K H, Treumann T, Winkeltau G, Schumpelick V. [Liver hemangioma. I. Diagnosis, spontaneous course, complications].  Leber Magen Darm. 1990;  20 218-223

Prof. Dr. med. Heinz-Jochen Gassel

Chirurgische Universitätsklinik und Poliklinik

Oberdürrbacher Straße 6

97080 Würzburg

Phone: 09 31/2 01/3 10 40

Fax: 09 31/2 01/3 10 49

Email: Gassel_H@chirurgie.uni-wuerzburg.de