Steroidal Saponins from Myriopteron extensum and Their Cytotoxic Activity

Abstract

Two new steroidal saponins, extensumsides A (1) and B (2), were isolated from the whole plants of Myriopteron extensum (Wight) K. Schum. Their structures were elucidated as 17β-uzarigenin-3-O-β-glucopyranosyl-(1→6)-β-glucopyranosyl-(1→4)-β-thevetopyranosyl-(1→4)-β-cymaropyranoside (1) and 12-(3-methylbut-2-enoyloxy)pregn-5-en-20-one 3-O-[β-cymaropyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-thevetopyranosyl-(1→4)-(6-O-sulfo-β-glucopyranoside)] (2) on the basis of chemical and spectral evidence. Extensumside A exhibited significant cytotoxicity against eight cancer cell lines with a mean GI₅₀ value of 0.346 μg/mL.

Key words

Myriopteron extensum - Asclepiadaceae - cytotoxic activity - extensumside A - extensumside B

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