Planta Med 2004; 70(1): 68-69
DOI: 10.1055/s-2004-815459
Letter
© Georg Thieme Verlag Stuttgart · New York

Taraxer-14-en-3β-ol, an Anti-Inflammatory Compound from Sterculia foetida L.

D. G. Naik1 , A. M. Mujumdar1 , R. J. Waghole1 , A. V. Misar1 , S. W. Annie Bligh2 , Alan Bashall2 , John Crowder2
  • 1Agharkar Research Institute, Pune, India
  • 2Institute of Health Research and Policy, London Metropolitan University, London, U.K.
Further Information

Publication History

Received: July 23, 2003

Accepted: November 8, 2003

Publication Date:
06 February 2004 (online)

Abstract

Taraxer-14-en-3β-ol (1) was shown to be the active ingredient in the leaves of Sterculia foetida L. The alcohol 1, its acetate and ketone showed anti-inflammatory activity against TPA induced mouse ear oedema with inhibition ratios of 60.0, 58.57 and 40.57 at 0.5 mg/ear, respectively. The percentage inhibition of inflammation increased with dose for each compound.

References

  • 1 Mujumdar A M, Naik D G, Waghole R J, Kulkarni D K, Kumbhojkar M S. Pharmacological studies on Sterculia foetida leaves.  Pharm Biol. 2000;  38 13-7
  • 2 Young J M, De Young L M. Pharmacological methods in the control of inflammation. In: Spector J, Back N, editors New York; Alan R. Liss, Inc 1989: pp 215-31
  • 3 Brooks C JW. Observations on taraxerol (skimmiol). J Chem Soc 1955: 1674-7
  • 4 Paul B D, Rao G S. Kapadia GJ. Isolation of myricadiol, myricitrin, taraxerol and taraxerone from Myrica cerifera L. root bark.  J Pharmaceutical Sci. 1974;  63 958-9
  • 5 Bates R B, Jacobsen N E, Setzer W N, Stessman C C. NMR assignments and conformation of taraxerenes.  Magnetic Resonance in Chemistry. 1998;  36 539-41
  • 6 De Young L, Kheifts J, Young J. Edema and cell in filtration in the phorbol treated mouse ear are temporally separate and can be differentially modulated by pharmacological agents.  Agents and Actions. 1989;  26 335-41

Dr. D. G. Naik

Chemistry Group

Agharkar Research Institute

Pune-411 004

India

Phone: +91-020-25653680

Fax: +91-020-25651542

Email: dgnpune@yahoo.co.in

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