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Synlett 2004(1): 122-124  
DOI: 10.1055/s-2003-43353
LETTER
© Georg Thieme Verlag Stuttgart · New York

Diastereopure Preparation of α-Benzotriazolyl 1-Azacycloalka[2,1-b][1,3]-oxazines and their Application as Versatile Chiral Precursors

Xuenong Xua,b, Jun Lub, Rui Lia,b, Zongming Geb, Yanmei Dongb, Yuefei Hu*b
a Department of Chemistry, Nanjing University, Nanjing 210093, P. R. China
b Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
Fax: +86(10)62771149; e-Mail: yfh@mail.tsinghua.edu.cn;
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Publication History

Received 3 October 2003
Publication Date:
26 November 2003 (online)

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Abstract

A group of diastereopure α-benzotriazolyl 1-azacyclo­alka[2,1-b][1,3]oxazines were prepared from non-racemic Betti base and they were employed as the versatile precursors for the preparation of chiral ligands and chiral substituted azacyclics with significant advantages in the stereoselectivity.

Key words

Betti base - chiral [1,3]oxazines - chiral ligands - chiral substituted azacyclics