Semin Thromb Hemost 2002; 28(6): 501-506
DOI: 10.1055/s-2002-36690
Copyright © 2002 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662

The M235T Variant of the Angiotensinogen Gene and the Body Mass Index Are Useful Markers for Prevention of Hypertension in Pregnancy: A Tree-Based Analysis of Gene-Environment Interaction

Gen Kobashi1 , Akira Hata2 , Koichi Shido1 , Kaori Ohta1 , Hideto Yamada3 , Seiichiro Fujimoto3 , Kiyotaro Kondo4
  • 1Division of Preventive Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • 2Department of Public Health, Asahikawa Medical College, Asahikawa, Japan
  • 3Division of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • 4The University of the Air, Chiba, Japan
Further Information

Publication History

Publication Date:
21 January 2003 (online)

ABSTRACT

We sought to perform a tree-based analysis of lifestyle risk factors for hypertension in pregnancy (HP) with univariate and multivariate analyses. Seventy-eight HP patients and 199 normal controls were recruited from primiparous women 20 to 34 years of age. Data from angiotensinogen (AGT) genotyping and data from a self-administered questionnaire about lifestyle were subjected to univariate and multivariate analyses. By dividing the subjects into two subgroups-those who possessed "the TT genotype of AGT" and "body mass index (BMI) < 24" and those who did not-we were able to examine the acquired risk factors for HP during pregnancy in these two groups. Multivariate analysis selected "mentally stressful condition" and "no antenatal training during pregnancy" in the former group, and "poorly balanced diet" in the latter group. Determination of factors obvious before pregnancy, such as genotype or prepregnancy BMI, may be useful for devising effective individualized strategies for preventing HP.

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