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DOI: 10.1055/s-2002-33469
Effects of Dietary Caloric Restriction and Aging on Thyroid Hormones of Rhesus Monkeys
Publication History
Received: 24 September 2001
Accepted after revision: 27 February 2002
Publication Date:
21 August 2002 (online)
![](https://www.thieme-connect.de/media/hmr/200207/lookinside/thumbnails/10.1055-s-2002-33469-1.jpg)
Abstract
Plasma levels of thyroid hormones - triiodothyronine (T3), thyroxin (T4), and thyroid-stimulating hormone (TSH) were measured in male and female rhesus monkeys (Macaca mulatta) fed either ad libitum or a 30 % calorie-restricted (CR) diet (males for 11 years; females for 6 years). The same hormones were measured in another group of young male rhesus monkeys during adaptation to the 30 % CR regimen. Both long- and shorter-term CR diet lowered total T3 in plasma of the monkeys. The effect appeared to be greater in younger monkeys than in older counterparts. No effects of CR diet were detected for either free or total T4, although unlike T3, levels of this hormone decreased with age. TSH levels also decreased with age, and were increased by long-term CR diet in older monkeys only. No consistent effects of shorter-term CR diet were observed for TSH. In the light of the effects of the thyroid axis on overall metabolism, these results suggest a possible mechanism by which CR diets may elicit their well-known beneficial ‘anti-aging’ effects in mammals.
Key words
Primate - Thyroxin - Triiodothyronine - Dietary Restriction
References
- 1 Yu B P. Modulation of aging processes by dietary restriction. Boca Raton: CRC Press 1994
- 2 Lane M A, Ingram D K, Roth G S. Beyond the rodent model: Caloric restriction in rhesus monkeys. Age. 1997; 20 45-56
- 3 Roth G S, Ingram D K, Lane M A. Caloric restriction in primates: Will it work and when will we know?. J Am Geriatrics Soc. 1999; 46 896-903
- 4 Roth G S, Ingram D K, Lane M A. Beneficial effects of caloric restriction and caloric restriction mimetics: Implications for humans. Ann NY Acad Sci. 2001; 928 305-315
- 5 Yu B P. Free radicals in aging. Boca Raton: CRC Press 1993
- 6 Masoro E J, Katz M S, McMahan C A. Evidence for the glycation theory of aging from the food-restricted model. J Gerontol Biol Sci. 1989; 44 B20-B29
- 7 Sabbatino F, Masoro E J, McMahan C A, Kuhn R W. Assessment of the role of the glucocorticoid system in aging processes and in the action of food restriction. J Gerontol Biol Sci. 1991; 46 B171-B179
- 8 Lane M A, Baer D J, Rumpler W V, Weindruch R, Ingram D K, Tilmont E M, Cutler R G, Roth G S. Calorie restriction lowers body temperature in rhesus monkeys consistent with a postulated anti-aging mechanism in rodents. Proc Natl Acad Sci USA. 1997; 93 4159-4164
- 9 Roth G S, Ingram D K, Lane M A. Slowing aging by caloric restriction. Nature Med. 1996; 1 414-415
- 10 McCarter R JM, McGee J R. Transient reduction of metabolic rate by food restriction. Am J Physiol. 1989; 257 E175-E179
- 11 Norman A W, Litwack G. Hormones. Orlando; Academic Press Inc 1987: 221-262
- 12 Sherwin R S. Influence of diet and carbohydrate on thyroid hormone metabolism. In: Blackburn GL, Bray GA (eds). Management of obesity by severe caloric restriction. Littleton; PSG Publishing 1985: 155-163
- 13 Blum J W, Schnyder W, Kunz P L, Blom A K, Bickel H, Schurch A. Reduced and compensatory growth: Endocrine and metabolic changes during food restriction and refeeding in steers. J Nutrition. 1985; 115 417-421
-
14 Merry B J, Holehan A M. The endocrine response to dietary restriction in the rat. In: Woodhead AD, Blackett AD, Holleander A (eds)
Molecular biology of aging. New York; Plenum Press 1985: 117-141 - 15 DeLany J P, Hansen B C, Bodkin M L, Hannah J, Bray G A. Long-term calorie restriction reduces energy expenditure in aging monkeys. J Gerontol Biol Sci. 1999; 54 B5-B11
- 16 Ingram D K, Cutler R G, Weindruch R, Renquist D M, Knapka J M, April M, Belcher C T, Clark M A, Hatcherson C D, Marriott B M, Roth G S. Dietary restriction and aging: The initiation of a primate study. J Gerontol Biol Sci. 1990; 45 B148-B163
- 17 Lane M A, Ingram D K, Cutler R G, Knapka J M, Barnard D E, Roth G S. Dietary restriction in non-human primates: Progress report on the NIA study. Ann NY Acad Sci. 1992; 673 36-45
- 18 Danforth E, Burger A G. The impact of nutrition on thyroid hormone physiology and action. Annu Rev Nutr. 1989; 9 201-227
- 19 Walford R L, Mock D, Verdery R, MacCallum T. Calorie-restriction in Biosphere 2: Alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a two-year period. J Gerontol Biol Sci. 2002; 57 in press
G. S. Roth, Ph.D.
Laboratory of Neurosciences, National Institute on Aging ·
5600 Nathan Shock Drive · Baltimore, MD 21224 · USA