Planta Med 2002; 68(6): 545-547
DOI: 10.1055/s-2002-32560
Letter
© Georg Thieme Verlag Stuttgart · New York

Inhibitory Effects of Natural Sesquiterpenoids Isolated from the Rhizomes of Curcuma zedoaria on Prostaglandin E2 and Nitric Oxide Production

Chae Hee Hong1 , Min Soo Noh2 , Woo Young Lee2 , Sang Kook Lee1
  • 1College of Pharmacy, Ewha Womans University, Korea
  • 2Pacific R&D Center, Pacific Corporation, Korea
Further Information

Publication History

December 4, 2001

January 12, 2002

Publication Date:
01 July 2002 (online)

Abstract

β-Turmerone and ar-turmerone, sesquiterpenoids isolated from the rhizome of Curcuma zedoaria, inhibited lipopolysaccharide (LPS)-induced prostaglandin E2 production in cultured mouse macrophage cell RAW 264.7 in a dose-dependent manner (IC50 = 7.3 μM for β-turmerone; IC50 = 24.0 μM for ar-turmerone). In addition, these compounds exhibited inhibitory effects on LPS-induced nitric oxide production in the cell system.

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  • 4 Pradelles P, Grassi J, Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: An alternative to radioimmunoassay.  Anal Chem. 1985;  57 1170-3
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Dr. Sang Kook Lee

College of Pharmacy

Ewha Womans University

11-1 Daehyun-dong

Seodaemun-ku

Seoul 120-750

Korea

Phone: +82-2-3277-3023

Fax: +82-2-3277-2851

Email: sklee@mm.ewha.ac.kr