Planta Med 2002; 68(6): 541-543
DOI: 10.1055/s-2002-32558
Letter
© Georg Thieme Verlag Stuttgart · New York

Antibacterial Activity of Calozeyloxanthone Isolated from Calophyllum Species Against Vancomycin-Resistant Enterococci (VRE) and Synergism with Antibiotics

Y. Sakagami1 , K. Kajimura1 , W. M. N. M. Wijesinghe2 , H. R. W. Dharmaratne2
  • 1Osaka Prefectural Institute of Public Health, Osaka, Japan
  • 2Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka
Further Information

Publication History

September 29, 2001

January 13, 2002

Publication Date:
01 July 2002 (online)

Abstract

Calozeyloxanthone (1) was re-isolated from the root bark of Calophyllum moonii, an endemic species of Sri Lanka, and found to be active against vancomycin-resistant Enterococci (VRE) and vancomycin-sensitive Enterococci (VSE) with MIC values of 6.25μg/ml and 12.5μg/ml, respectively. Further, a marked synergism between 1 and vancomycin hydrochloride (VCM) against VRE was also observed. These findings suggest that 1 in combination with VCM against VRE may be useful in controlling VRE infections.

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Dr. Y. Sakagami

Osaka Prefectural Institute of Public Health

1-3-69 Nakamichi

Higashinari-ku

Osaka 537-0025

Japan

Phone: +81-66972-1321

Fax: +81-6-6972-2393

Email: sakagami@iph.pref.osaka.jp