New Technologies to Detect Static and Dynamic Upper Airway Obstruction During Sleep

ABSTRACT

Increase in upper airway resistance is the main patho-physiological feature in the obstructive breathing disorders during sleep. Upper airway events may be divided into two main groups: static obstruction (apneas) and dynamic obstruction (hypopneas, flow limitation, and snoring). This classification is useful to provide better information about the patho-physiological mechanisms of obstruction and to better define the diagnostic tools necessary for detecting abnormal respiratory events during sleep. Detection of dynamic obstruction requires sensors with a good frequency response. As thermistors have a poor dynamic response, they are not efficient in detecting the dynamic obstruction but are good enough to detect static obstruction. Nasal prongs (NP) connected a to pressure transducer and the impedance signal measured by the forced oscillation technique (FOT) are relatively new tools to noninvasively investigate dynamic upper airflow obstruction during sleep. FOT provides a direct index of the magnitude of airway obstruction and, therefore, of the upper airway patency, even under conditions of no flow (apneas). NP are aimed at assessing flow. Thus, both techniques have a different scope. The main advantages of NP are that they are easy to use and do not require sophisticated technology, while FOT needs a more complex instrumentation. For clinical routine studies NP are probably the best and simplest method for assessing the different respiratory events during sleep. However, FOT would be particularly useful in selected applications such as assessing upper airway patency in some central apneas; interpreting the irregular pattern of breathing during REM sleep; in better characterizing the inspiratory flow-limited breaths classified as intermediate; and in studying upper airway mechanics.

KEYWORD

Sleep apnea syndrome - hypopnea - upper airway resistance syndrome (UARS) - CPAP titration - forced oscillation technique - respiratory impedance

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