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Horm Metab Res 2001; 33(8): 458-462
DOI: 10.1055/s-2001-16937
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© Georg Thieme Verlag Stuttgart · New York

Lipoprotein Lipase and Cholesterol Transfer Activities of Lean and Obese Zucker Rats

J. Peinado-Onsurbe, M. Blay, J. Julve, J. A. Fernández-López, X. Remesar, M. Alemany
  • Centre de Recerca en Nutrició i Ciència dels Aliments, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
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Publication History

Publication Date:
04 September 2001 (online)

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Adult female lean and obese Zucker rats maintained under standard conditions were used for the estimation of plasma, liver and white adipose tissue (WAT) activity of lipoprotein lipase, plasma and liver hepatic lipase and plasma lecithin-cholesterol acyltransferase. No differences in plasma or tissue levels of lipoprotein lipase between lean and obese rats were detected, but the larger WAT size of the obese rats resulted in higher lipase activity per unit of rat weight. Hepatic lipase levels in plasma were higher in the obese, but in liver, the higher activity was found in lean rats. No significant differences were found for lecithin-cholesterol acyltransferase activity, except when the levels in the HDL fraction were expressed per unit of protein weight, showing lower activity in the obese rats. In conclusion, the essentially maintained enzyme activities in obese rat tissues suggest that they cannot explain the deficient lipoproteins processing of obese rats, and, consequently their dislipidaemia.

Key words:

Obesity - Zucker fa/fa Rat - Lipoproteins - Lipoprotein Lipase - Hepatic Lipase - Lecithin-Cholesterol Acyltransferase

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Prof. Dr. Marià Alemany

Centre de Recerca en Nutrició i Ciència dels Aliments
Facultat de Biologia
Universitat de Barcelona

Av. Diagonal, 645
08028 Barcelona
Spain


Email: alemany@bio.ub.es

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