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Synlett 2001; 2001(9): 1343-1363
DOI: 10.1055/s-2001-16770
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Synthesis of Polymeric Enzyme-like Catalysts

Junghun Suh*
  • *School of Chemistry and Molecular Engineering and Center for Molecular Catalysis, Seoul National University, Seoul 151-742, Korea; Fax + 82-2-874-3704; E-mail: jhsuh@snu.ac.kr
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Publication Date:
28 August 2001 (online)

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This account summarizes our recent achievements in synthesis of enzyme-like catalysts on the backbones of synthetic polymers. To synthesize effective artificial enzymes, it is desirable to design artificial active sites comprising binding unit and convergent catalytic groups. We developed several novel methodologies to position several catalytic elements in proximity on highly branched polymers. The resulting polymers manifested high catalytic effects in peptide hydrolysis. Some of the artificial peptidases we prepared achieved faster rates compared with catalytic antibodies with peptidase activity, approaching the level of catalytic rates achieved by natural peptidases. We have also achieved stereoselective hydrolysis of unactivated amides and effective hydrolysis of DNA molecules.

artifical enzymes - polymers - hydrolysis - peptides - DAN

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