Download PDF
Synthesis 2001; 2001(3): 0413-0418
DOI: 10.1055/s-2001-11440
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A One-Pot Synthesis of 2,3-Dihydro-2-Thioxothieno[2,3-d]Thiazoles

Mohamed T. Omar* , Nadia K. El-Asar, Khaled F. Saied
  • *Chemistry Department, Faculty of Science, Ain Shams University Abbassia, Cairo, Egypt; E-mail: osmanyo@intouch.com
Further Information

Publication History

Publication Date:
31 December 2001 (online)

  PDF Download  Permissions and Reprints All articles of this category

A variety of 3,5-disubstituted-2,3-dihydro-2-thioxothieno[2,3-d]thiazoles 3 a - h including alkyl-, aryl- and heteryl-substituents were synthesized in excellent yields in a one pot reaction between 3-substituted-5-(2-aryl (or heteryl)-2-oxoethyl)-4-oxo-2-thioxo-1,3-thiazolidines 1 a - h and either tetraphosphorous decasulfide (Method A) or Lawesson's reagent (Method B). However, fair yields of 3 were also obtained along with unknown oily products when the (E,Z)-5-(2-aryl-2-oxoethylidene) derivatives 2 f,g were similarly treated with the same reagents. Structures of products were supported by microanalytical and spectral evidence. A rationalization for the route of conversion is given.

1,3-thiazolidines - thionation - 1,2-dithiines - thiazoles - fused thieno-bithienyls - sulfur - heterocycles

      >