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Synlett 2001; 2001(2): 0254-0256
DOI: 10.1055/s-2001-10776
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Suzuki Arylation of 1,1-Dibromo-1-alkenes: Synthesis of Tetra-substituted Alkenes

Annette Bauer* , Michael W. Miller, Susan F. Vice, Stuart W. McCombie
  • *Department of Chemical Research, Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, New Jersey 07033-1300, USA; Fax (908) 740-7441; E-mail: michael.miller§spcorp.com
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Publication History

Publication Date:
31 December 2001 (online)

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1,1-Dibromo-1-alkenes were coupled with a variety of aryl boronic acids using Suzuki conditions (PdCl2(PPh3)2/Na2CO3/THF-H2O or DME-H2O/65-90 °C). The 1,1-dibromo-1-alkenes were prepared from ketones, and thus, the overall process furnished tetra-substituted alkenes in a very efficient manner.

Suzuki reaction - cross-coupling - arylations - palladium - alkenes

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