Planta Med 2000; 66(8): 770-772
DOI: 10.1055/s-2000-9604
Letter

© Georg Thieme Verlag Stuttgart · New York

Antinociceptive Profile of Hodgkinsine

T. A. Amador1, 2 , L. Verotta3 , D. S. Nunes4 , E. Elisabetsky1, 2,*
  • 1 Curso de Pós-graduação em Ciências Biológicas-Bioquímica, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS, Brazil
  • 2 Departamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS, Brazil
  • 3 Dipartimento di Chimica Organica e Industriale, Università degli Studi, Milan, Italy
  • 4 Departamento de Química, Universidade Estadual de Ponta Grossa, Ponta Grossa/Paraná, Brazil
Further Information

Publication History

December 2, 1999

June 24, 2000

Publication Date:
31 December 2000 (online)

Abstract

To further understand the mechanism of analgesic activity and structural requirements of pyrrolidinoindoline alkaloids identified in Psychotria colorata, we here report the analgesic activity of the trimer hodgkinsine on thermal and chemical models of analgesia. Results show that hodgkinsine produces a dose-dependent naloxone reversible analgesic effect in thermal models of nociception, suggesting that activation of opioid receptors participates in hodgkinsine's mode of action. Hodgkinsine shows a potent dose-dependent analgesic activity against capsaicin-induced pain, indicating the participation of NMDA receptors in hodgkinsine-induced analgesia. Such a dual mechanism of action may be of interest for developing innovative analgesics.

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