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Synlett 2000; 2000(11): 1603-1607
DOI: 10.1055/s-2000-7917
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A Rapid Approach for the Optimisation of Polymer Supported Reagents in Synthesis

Craig Jamieson* , Miles S. Congreve, David F. Emiabata-Smith, Steven V. Ley
  • *Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK; E-mail: svl1000@cam.ac.uk
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Publication Date:
31 December 2000 (online)

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The technique of Design of Experiments (DoE) was employed to facilitate the rapid automated optimisation of amide formation using a polymer supported carbodiimide system. Using an optimised set of reaction conditions, an array of 80 compounds was synthesised in a 96-well plate with the reagent being delivered via an IRORITM kan to each individual well.

Design of Experiments - combinatorial chemistry - reaction optimisation

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