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Synlett 2000; 2000(11): 1577-1580
DOI: 10.1055/s-2000-7910
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A Convenient Method for the Synthesis and One-Pot Reaction of Acyl Chlorides Using a Scavenging Resin

Christian Girard* , Isabelle Tranchant, Pierre-Antoine Nioré, Jean Herscovici
  • *Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire & Cellulaire UMR 7001, Ecole Nationale Supérieure de Chimie de Paris, 11, rue Pierre & Marie Curie, 75005 Paris, France; Fax +33 1 53 10 12 93; E-mail: cgirard@ext.jussieu.fr
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Publication Date:
31 December 2000 (online)

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A simple, efficient and fast method for the preparation of acyl halides from fatty carboxylic acids using a solid phase scavenging approach is presented herein. The title compounds can then be isolated, used as a solution or react in one-pot to form esters and amides with good to excellent yields.

acyl chlorides - solid phase - acylations - amides - esters

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