Fluvastatin combined with 17β-estradiol: Effect on the oxidation of human low density lipoprotein

Summary:

The in vitro effect of a statin and an estrogen on oxidation of human LDL was investigated for the first time, comparing the monosubstances fluvastatin and 17β-estradiol as well as the effect of the combination. Fluvastatin significantly delayed the onset of LDL oxidation (controls = 90 min) by 23 min at 1 μM, by 110 min and by 221 min at 5 and 10 μM, respectively. 17β-estradiol significantly impeded the onset by 70 min at 1 μM and by more than 300 min at 5 and 10 μM. The combination of 1 μM 17β-estradiol with 1, 5 and 10 μM fluvastatin showed an additive antioxidative effect; the onset was delayed by 100 min, by 167 min, and by more than 300 min, respectively. It can be concluded that treatment of postmenopausal women with fluvastatin and 17β-estradiol may have not only beneficial effects on lipid disorders but may also elicit a direct potent anti-atherosclerotic action on the vasculature.

Key words:

Fluvastatin - 17β-estradiol - LDL-oxidation

References

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1 * p < 0.05; ** p < 0.01 compared to control value